In this issue, Chen et al. show that genetic knockout of Piezo2 in SOX2 medulloblastoma cells decreased local tissue stiffness, increased drug delivery across the blood-tumor barrier, and improved survival, uncovering a mechanosensitivity-dependent mechanism of action in a mouse model of pediatric brain tumors.
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| http://dx.doi.org/10.1016/j.neuron.2022.12.008 | DOI Listing |
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Design, Modeling, and Validation of a Compact, Energy-Efficient Mixing Screw for Sustainable Polymer Processing.
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January 2025
Department of Mechanical Engineering, University of Massachusetts Lowell, Lowell, MA 01854, USA.
This study presents the design, modeling, and validation of a mixing screw for energy-efficient single-screw extrusion. The screw features a short length-to-diameter (L/D) ratio of 8:1 and incorporates double flights with variable pitch and counter-rotating mixing slots. These features promote enhanced plastication by breaking up the solid bed and improving thermal homogeneity through backflow mechanisms relieving a 3.
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Foods
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Department of Chemical Organic Technology and Polymeric Materials, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Pułaskiego 10, 70-322 Szczecin, Poland.
In order to establish the differences in packaging containing various essential oils, polylactide (PLA)-based polymeric films incorporating poly(ethylene glycol) (PEG), clove (C), grapefruit (G), rosemary (R), and tea tree (T) essential oils were obtained and subsequently analyzed. In addition to examining structure and morphology, the polymer films underwent analyses that are particularly important with regard to contact with food. Mechanical and antioxidant properties, water vapor transmission rate (WVTR), and analysis of barrier properties against ultraviolet (UV) radiation, as well as the migration of ingredients into food simulants such as 10% / solutions of ethanol, 3% / acetic acid solution, and isooctane, were among the critical studies conducted.
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Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia; Scientific Center for Translational Medicine, Sirius University of Science and Technology, 354340, Sirius, Krasnodar Region, Russia. Electronic address:
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View Article and Find Full Text PDF[Patients' experiences of long-covid neuropsychological symptoms in Catalonia: A phenomenological study].
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Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Mataró, España; Institut d'Investigació Germans Trias i Pujol Research Institute (IGTP), Badalona, España; Departamento de Medicina, Facultad de Medicina, Universitat de Girona, Gerona, España.
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Food Chem
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School of Food Science and Engineering, Yangzhou University, Jiangsu 225127, China. Electronic address:
The broad application of starch films has been significantly limited by their insufficient hydrophobicity and antibacterial activity. To overcome these challenges, this study developed a new starch film by incorporating polyvinyl alcohol (PVA) and chlorogenic acid. The study explored the impact of PVA polymerization on the physical and functional characteristics of the resulting films, with particular emphasis on enhancing antimicrobial functionality by incorporating chlorogenic acid.
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