AI Article Synopsis
- Microglia are special cells in the brain that help get rid of harmful stuff like amyloid-β (Aβ), which is linked to Alzheimer's disease.
- Researchers found out that these microglia can "feel" Aβ plaques because of a protein called Piezo1 that senses how stiff the plaques are.
- This discovery might help scientists find new ways to treat Alzheimer's disease in the future.
Article Abstract
Classically, microglia recognize and internalize amyloid-β (Aβ) via it binding to cell surface receptors. In this issue of Neuron, Hu et al. report that microglia "feel" and internalize Aβ plaques using the stiffness-sensing channel Piezo1. This could allow new approaches to treating Alzheimer's disease.
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| http://dx.doi.org/10.1016/j.neuron.2022.11.014 | DOI Listing |
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