AI Article Synopsis
- Defects in myofibroblast function can lead to issues with wound healing across different tissue types.
- The study introduces an easy method using skin-punch biopsies in mouse models to identify wound closure problems without needing advanced surgical skills or costly tools.
- Results from this approach could provide a basis for deciding whether to investigate further into how myofibroblast function defects impact skin wound healing.
Article Abstract
Defects in myofibroblast function may cause wound healing defects in a variety of tissue types. Here we describe a simple skin-punch biopsy approach to screen mouse models for defects in wound closure that does not require extensive surgical training or expensive equipment. Experimental results may serve as an initial proof of concept to determine whether further investigation is necessary or if defects in myofibroblast function observed in other systems also result in reduced skin wound healing.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826969 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2022.101989 | DOI Listing |
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