An efficient nickel-catalyzed cross-coupling for the synthesis of 2-sulfonylthiazoles from readily available 2-chlorobenzothiazoles and sodium sulfinates has been developed. A variety of 2-chlorobenzothiazoles and sulfinates having a diverse range of substitution patterns can undergo the coupling process successfully at room temperature. Avoiding the use of precious catalysts and sensitive ligands, moderate to excellent yields of various 2-sulfonylthiazoles were observed.
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http://dx.doi.org/10.1039/d2cc06107d | DOI Listing |
Chem Commun (Camb)
January 2023
Jiangxi Province Key Laboratory of Synthetic Chemistry, East China University of Technology, Nanchang, 330013, China.
An efficient nickel-catalyzed cross-coupling for the synthesis of 2-sulfonylthiazoles from readily available 2-chlorobenzothiazoles and sodium sulfinates has been developed. A variety of 2-chlorobenzothiazoles and sulfinates having a diverse range of substitution patterns can undergo the coupling process successfully at room temperature. Avoiding the use of precious catalysts and sensitive ligands, moderate to excellent yields of various 2-sulfonylthiazoles were observed.
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