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Role of angiomotin family members in human diseases (Review).
Exp Ther Med
June 2024
Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Article Synopsis
- Angiomotin (Amot) family members, including Amot, Amotl1, and Amotl2, interact with angiostatins and play significant roles in processes like embryonic development, angiogenesis, and tumorigenesis.
- They are involved in regulating important signaling pathways such as Hippo, AMPK, and mTOR, impacting neural stem cell differentiation and synaptic functions.
- The review consolidates studies on Amot family regulation and their physiological/pathological roles, aiming to provide insights for future cancer research and potential clinical applications.
Impact of circulating angiomotin and angiostatin on clinical variables in patients with asthma.
Ann Allergy Asthma Immunol
July 2024
Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
Angiomotin and angiostatin as asthma biomarkers: Implications for the regulation of airway remodeling and inflammation.
Allergy
June 2023
Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.
Oncol Rep
July 2021
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Glioblastoma multiforme (GBM) is the most prevalent type of malignant cancer in the adult central nervous system; however, its mechanism remains unclear. Angiomotin‑like 2 (AMOTL2) is a member of the motin family of angiostatin‑binding proteins. It has been reported as an oncogene in cervical and breast cancer, but its association with glioma remains unknown.
View Article and Find Full Text PDFMultimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin.
Eur J Med Chem
January 2015
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:
Roxithromycin (RXM) is a semi-synthetic fourteen-membered macrolide antibiotic that shows anti-angiogenic activity in solid tumors. In the present study, we conducted biopanning of T7 phage-displayed peptides either on a 96-well formatted microplate, a flow injection-type quartz-crystal microbalance (QCM) biosensor, or a cuvette-type QCM. RXM-selected peptides of different sequence, length and number were obtained from each mode of screening.
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