AI Article Synopsis
- A detailed pathological study is crucial for understanding specific diseases in inbred mouse strains, distinguishing between spontaneous lesions and experimental effects.
- This research identifies a new condition in male C57BL/6NCrl mice, characterized by large vacuoles in muscle fibers without signs of weakness or other organ involvement.
- The investigation showed fiber size changes and indicated a disruption in autophagy, differentiating it from another condition related to tubular aggregates.
Article Abstract
A comprehensive pathological analysis of inbred strains is essential to define strain-specific spontaneous lesions and to understand whether a specific phenotype results from experimental intervention or reflects a naturally occurring disease. This study aimed to report and describe a novel condition affecting the skeletal muscles of an inbred C57BL/6NCrl mouse colony characterised by large sarcoplasmic vacuoles in the muscle fibres of male mice in the subsarcolemmal spaces and the intermyofibrillary network. There was no muscle weakness, loss of ambulation or cardiac/respiratory involvement. Post-mortem evaluation and histological analysis excluded the presence of pathological accumulations or lesions in other tissues and organs. Changes were seen in fibre size, with many hypotrophic and some slightly hypertrophic fibres. Histological, immunohistochemical and molecular analyses of the vacuolar content revealed dysregulation of the autophagy machinery while ruling out a morphologically similar condition marked by the accumulation of tubular aggregates.
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| http://dx.doi.org/10.1177/00236772221138942 | DOI Listing |
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