Purpose: To investigate the usefulness and effectiveness of a dual beam-current transformer (BCTs) design to monitor and record the beam dosimetry output and energy of pulsed electron FLASH (eFLASH) beams in real-time, and to inform on the usefulness of this design for future eFLASH beam control.

Methods: Two BCTs are integrated into the head of a FLASH Mobetron system, one located after the primary scattering foil and the other downstream of the secondary scattering foil. The response of the BCTs was evaluated individually to monitor beam output as a function of dose, scattering conditions, and ability to capture physical beam parameters such as pulse width (PW), pulse repetition frequency (PRF), and dose per pulse (DPP), and in combination to determine beam energy using the ratio of the lower-to-upper BCT signal.

Results: A linear relationship was observed between the absorbed dose measured on Gafchromic film and the BCT signals for both the upper and lower BCT (R  > 0.99). A linear relationship was also observed in the BCT signals as a function of the number of pulses delivered regardless of the PW, DPP, or PRF (R  > 0.99). The lower-to-upper BCT ratio was found to correlate strongly with the energy of the eFLASH beam due to differential beam attenuation caused by the secondary scattering foil. The BCTs were also able to provide accurate information about the PW, PRF, energy, and DPP for each individual pulse delivered in real-time.

Conclusion: The dual BCT system integrated within the FLASH Mobetron was shown to be a reliable monitoring system able to quantify accelerator performance and capture all essential physical beam parameters on a pulse-by-pulse basis, and the ratio between the two BCTs was strongly correlated with beam energy. The fast signal readout and processing enables the BCTs to provide real-time information on beam output and energy and is proposed as a system suitable for accurate beam monitoring and control of eFLASH beams.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924113PMC
http://dx.doi.org/10.1002/acm2.13891DOI Listing

Publication Analysis

Top Keywords

beam
12
beam parameters
12
scattering foil
12
dual beam-current
8
beam-current transformer
8
output energy
8
eflash beams
8
eflash beam
8
flash mobetron
8
secondary scattering
8

Similar Publications

Purpose: We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T relaxation time measurements.

Methods: We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T values of different renal compartments between control and external beam radiotherapy or α-particle-emitting actinium-225 radiolabeled antibody-treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test.

View Article and Find Full Text PDF

Introduction: There is a scarcity of studies in which both alveolar bone remodeling and root resorption are simultaneously assessed and compared against possible influencing factors such as rate of retraction and change in inclination. The aim of our study was to assess the changes in the alveolar bone thickness and root length of the maxillary anterior teeth after retraction and correlate it to the potential influencing factors, namely rate of retraction and change in inclination.

Subjects And Methods: Ten patients requiring upper premolar extraction as part of their treatment were included in the study.

View Article and Find Full Text PDF

Regenerative endodontic therapy (RET) of young permanent teeth with necrotic pulps and apical periodontitis in young people, deciduous tooth pulp may be utilized as a natural, biologic scaffold. Recent developments in stem cell biology and material sciences are beneficial for new treatment methods. Previously traumatized and necrotic young permanent tooth was treated with RET protocol.

View Article and Find Full Text PDF

Purpose: In prostate cancer patients, high radiation doses to the urethra have been associated with an increased risk of severe genitourinary toxicity following dose-escalated radiotherapy. Urethra-sparing techniques have emerged as a promising approach to reduce urinary toxicity. This international survey aims to evaluate current global practices in urethra-sparing and explore future directions for the implementation of this technique in external beam radiotherapy (EBRT) for prostate cancer.

View Article and Find Full Text PDF

Background: The choice of treatment for subcondylar fractures in children and adolescents remains a controversial issue. The aim of this study was to evaluate the association between the treatment modality of subcondylar fractures and functional outcomes at the six-month follow-up.

Methods: This retrospective study examined a cohort of children and adolescents with unilateral or bilateral subcondylar fractures treated at a level 1 trauma center over a five-year period.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!