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Assessment of C Fibers Evoked Potentials in Healthy Subjects by Nd : YAP Laser. | LitMetric

AI Article Synopsis

  • Laser stimuli activate both Ad- and C-fibers, but the detectable laser evoked potentials (LEPs) mainly reflect the Ad-fibers, with C-fiber responses being less prominent.
  • The study aimed to assess multichannel ultralate LEPs (U-LEPs) from Nd:YAP laser pulses on healthy volunteers to analyze C-LEPs from trigeminal and somatic sites.
  • Results showed detectable U-LEPs linked to C-fiber activation, particularly at the trigeminal level, indicating potential for understanding C-fiber involvement in sensations related to warmth in clinical settings.

Article Abstract

Introduction: Although laser stimuli activate both Ad- and C-fibres, the corresponding laser evoked potentials (LEPs) remain restricted to the Ad-fibers input, while the C-fibers related potential is hardly detectable.

Aims: To evaluate multichannel ultralate LEPs (U-LEPs) by using Nd : Yap laser pulses in healthy volunteers to stimulation of face and lower and upper limbs, in order to estimate the reliability of C-LEPs elicited from both trigeminal and somatic sites.

Methods: Twenty healthy volunteers participated in two stimulation sessions to record A-LEPs and C-LEPs. We used a Nd : YAP Laser and 62 EEG recording electrodes. Stimuli parameters were set to activate either small myelinated (A), eliciting purely warmth sensations, or unmyelinated (C) afferents, and eliciting pinprick sensations.

Results: At the trigeminal level, we obtained a negative-positive complex in a time interval compatible with the C fibers activation. In the somatic districts, the averaged responses consisted of an earlier negative-positive complex, followed by a later one. Single trials analysis of U-LEPs showed a maximal positive peak in a time interval in the range of C fibers. Topographical analysis of U-LEPs resembled that of LEPs. All subjects exhibited readable U-LEPs in at least 2 stimulated sites. . A purely warmth sensation seems to correspond to A and C-fibers coactivation, at least in the somatic districts. While the related cortical waves seem hardly readable, their total absence could be a sign of systemic involvement of warm related C-fibers in specific clinical conditions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807303PMC
http://dx.doi.org/10.1155/2022/7737251DOI Listing

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