AI Article Synopsis
- A chiral phosphoric acid catalyst is used to facilitate an enantioselective aza-Friedel-Crafts reaction between 5-aminopyrazole derivatives and cyclic ketimines.
- This process results in the production of pyrazole-derived C2-quaternary indolin-3-ones with both high enantioselectivity and regioselectivity.
- The reaction can be scaled up to gram quantities without losing yield or enantioselectivity, demonstrating its practical application.
Article Abstract
A chiral phosphoric acid-catalyzed enantioselective aza-Friedel-Crafts reaction of 5-aminopyrazole derivatives with cyclic ketimines attached to a neutral functional group is reported. This protocol allows the formation of pyrazole-based C2-quaternary indolin-3-ones with high enantioselectivities and regioselectivities. Moreover, gram-scale synthesis of the 5-aminopyrazole-based C2-quaternary indolin-3-ones was performed, with no decrease in the yield and enantioselectivity.
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| http://dx.doi.org/10.1002/chem.202203914 | DOI Listing |
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