Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.asjsur.2022.12.093 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comprehensive single-cell and bulk transcriptomic analyses to develop an NK cell-derived gene signature for prognostic assessment and precision medicine in breast cancer.
Front Immunol
November 2024
National Key Laboratory of Immunity & Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China.
Background: Natural killer (NK) cells play crucial roles in mediating anti-cancer activity in breast cancer (BRCA). However, the potential of NK cell-related molecules in predicting BRCA outcomes and guiding personalized therapy remains largely unexplored. This study focused on developing a prognostic and therapeutic prediction model for BRCA by incorporating NK cell-related genes.
View Article and Find Full Text PDFExploring natural killer cell-related biomarkers in multiple myeloma: a novel nature killer cell-related model predicting prognosis and immunotherapy response using single-cell study.
Clin Exp Med
April 2024
Department of Medical, Xi'an Gem Flower Changqing Hospital, No. 20 Changqing West Road, Xi'an, 710201, Shaanxi, People's Republic of China.
Article Synopsis
- The study investigates the role of natural killer (NK) cells in the progression of multiple myeloma (MM) using advanced single-cell analysis techniques to identify relevant biomarkers.
- Researchers conducted a thorough examination of NK cells and related genes, leading to the creation of a risk model that predicts patient outcomes based on these biomarkers.
- The findings suggest significant differences in immune cell infiltration between high and low-risk groups, ultimately aiding in the identification of potential drug targets to improve immunotherapy for MM.
Natural killer cell-related prognosis signature predicts immune response in colon cancer patients.
Front Pharmacol
November 2023
Department of Breast, Maternal and Child Healthcare Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Natural killer (NK) cells are crucial components of the innate immune system that fight tumors and viral infections. Patients with colorectal cancer (CRC) have a poor prognosis, and immunotherapeutic tools play a key role in the treatment of CRC. Public data on CRC patients was collected from the TCGA and the GEO databases.
View Article and Find Full Text PDFA Novel Natural Killer Cell-related Gene Signature for Improving the Prediction of Prognosis and Immunotherapy Response in Bladder Cancer.
Comb Chem High Throughput Screen
July 2024
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Background: Bladder cancer (BLCA) is a commonly diagnosed cancer worldwide that exhibits high rates of recurrence and metastasis. Immunotherapy is increasingly being recognised in the clinical management of bladder cancer. In addition, the prospect of developing Natural Killer (NK) cell-related immunotherapy is promising in BLCA.
View Article and Find Full Text PDFContribution of natural killer cells in innate immunity against colorectal cancer.
Front Oncol
January 2023
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Natural killer cells are members of the innate immune system and promote cytotoxic activity against tumor or infected cells independently from MHC recognition. NK cells are modulated by the expression of activator/inhibitory receptors. The ratio of this activator/inhibitory receptors is responsible for the cytotoxic activity of NK cells toward the target cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!