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Health equity engineering: Optimizing hope for a new generation of healthcare.
J Clin Transl Sci
May 2024
Department of Statistics, Virginia Tech, Blacksburg, VA, USA.
Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated biological aging and early morbidity and mortality.
View Article and Find Full Text PDFTranscatheter Valve Replacement in Severe Tricuspid Regurgitation.
N Engl J Med
January 2025
From Columbia University Irving Medical Center, New York (R.T.H., M.B.L., S.K.K.); Cedars-Sinai Medical Center, Los Angeles (R.M., M.M.), and Stanford University, Stanford (R.P.S., C.H.) - both in California; Piedmont Heart Institute, Marcus Heart Valve Center, Atlanta (V.H.T., P.Y.); Northwestern University Feinberg School of Medicine, Chicago (C.J.D., A.N.); Henry Ford Hospital, Detroit (B.O., J.L.); Oregon Health and Science University, Portland (F.Z., S.C.); Mayo Clinic, Rochester, MN (M.E., S.P.); Baylor Scott and White Heart Hospital Plano (R.S., M.S., P.A.G., M.J.M.) and Baylor Scott and White Research Institute Cardiac Imaging Core Laboratory (P.A.G., A.S.) - both in Plano, TX; Intermountain Medical Center, Murray, UT (B.W., N.K.S.); Christ Hospital, Cincinnati (S.G., T.S.-D.), and the Cleveland Clinic Foundation, Cleveland (S.K., S.C.H.); Heart Center Leipzig at Leipzig University, Leipzig (H.T.), and University Medical Center Mainz, Mainz (P.L.) - both in Germany; Morristown Medical Center, Morristown, NJ (R.K., K.K.); and the University of Virginia, Charlottesville (D.S.L., D.F.).
Article Synopsis
- A clinical trial was conducted with 400 patients suffering from severe tricuspid regurgitation, comparing outcomes between those who received transcatheter tricuspid-valve replacement alongside medical therapy and those who received medical therapy alone.
- The primary outcome measured included death rates, hospitalizations due to heart failure, and improvements in quality of life and functional capacity, showing a significant advantage for the valve-replacement group.
- After one year, the valve-replacement group demonstrated better overall health outcomes, although there was a higher incidence of severe bleeding compared to the control group.
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.
Mol Cell
September 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, School of Marine Sciences, Ningbo University, Ningbo 315211, P.R. China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo 315211, P.R. China; Key Laboratory of Aquacultural Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, P.R. China. Electronic address:
NLRP3 inflammasome activation, essential for cytokine secretion and pyroptosis in response to diverse stimuli, is closely associated with various diseases. Upon stimulation, NLRP3 undergoes subcellular membrane trafficking and conformational rearrangements, preparing itself for inflammasome assembly at the microtubule-organizing center (MTOC). Here, we elucidate an orchestrated mechanism underlying these ordered processes using human and murine cells.
View Article and Find Full Text PDFPredicting mortality after transcatheter aortic valve replacement using preprocedural CT.
Sci Rep
May 2024
Computer Vision Laboratory, ETH Zurich, 8092, Zurich, Switzerland.
Transcatheter aortic valve replacement (TAVR) is a widely used intervention for patients with severe aortic stenosis. Identifying high-risk patients is crucial due to potential postprocedural complications. Currently, this involves manual clinical assessment and time-consuming radiological assessment of preprocedural computed tomography (CT) images by an expert radiologist.
View Article and Find Full Text PDFMortality in patients with normal left ventricular function requiring emergency VA-ECMO for postcardiotomy cardiogenic shock due to coronary malperfusion.
PLoS One
March 2024
Department of Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany.
Article Synopsis
- The study analyzes outcomes of patients with normal left ventricular ejection fraction (LVEF) who needed venoarterial extracorporeal membrane oxygenation (VA-ECMO) due to postcardiotomy cardiogenic shock (PCCS) from coronary issues.
- It is based on a retrospective analysis of 59 patients treated between May 1998 and May 2018, revealing a high 30-day mortality rate of 50.8% and notable complications in most patients.
- Key predictors of mortality include high lactate levels before VA-ECMO, delays in revascularization, and the presence of peripheral arterial disease, suggesting that timely intervention is critical for improving survival chances.
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