Purpose: Myocardial blood flow (MBF) and myocardial flow reserve (MFR) are measurable by N-NH positron emission tomography (PET). MFR, which is the ratio of MBF under adenosine stress to MBF at rest, is prognostically valuable. The ASNC imaging guidelines/SNMMI procedure standards recommend using 2-3 mm pixels, and pixel size does differ between institutions. We sought to evaluate the effects of pixel sizes on the quantitative values calculated from N-NH PET images.
Methods: Thirty consecutive patients with ischemic heart disease who underwent N-NH PET were retrospectively enrolled. Dynamic images were quantified using PMOD's cardiac PET analysis tool (pixel sizes: 3.18, 2.03, and 1.59 mm). MBF under adenosine stress, MBF at rest, and MFR for the right coronary artery (RCA) region, left anterior descending artery region, and left circumflex coronary artery branch region innervation regions were calculated at each pixel size and compared.
Results: Quantitative values did not significantly differ according to pixel size in any of the regions. However, MFR values for the RCA fluctuated the most. Ischemic and non-ischemic regions remained visually discernible in qualitative images, with no variation in quantitative values, regardless of pixel size.
Conclusions: Quantitative values were not significantly affected by pixel sizes within the recommended range of 2-3 mm. Values for the RCA region may have been overestimated, but this was true for all pixel sizes.
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http://dx.doi.org/10.1007/s10554-022-02639-3 | DOI Listing |
Light Sci Appl
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School of Optoelectronic Engineering, Changchun University of Science and Technology, Changchun 130022, China.
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Breast cancer ranks as the second most prevalent cancer globally and is the most frequently diagnosed cancer among women; therefore, early, automated, and precise detection is essential. Most AI-based techniques for breast cancer detection are complex and have high computational costs. Hence, to overcome this challenge, we have presented the innovative LightweightUNet hybrid deep learning (DL) classifier for the accurate classification of breast cancer.
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