AI Article Synopsis
- The COVID-19 pandemic highlighted the importance of developing new prophylactic vaccines, including those that combine DNA and protein elements.
- A combined vaccine was created using the full-length spike protein and the recombinant receptor-binding domain from the SARS-CoV-2 virus, produced in CHO-K1 cells.
- This combined DNA/protein vaccine demonstrates the advantages of both subunit and DNA vaccines, stimulating both humoral and cellular immune responses.
Article Abstract
During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such platform is the creation of vaccines combining DNA and protein components in one construct. For the creation of DNA vaccine, we chose the full-length spike protein (S) of the SARS-CoV-2 virus and used the recombinant receptor-binding domain (RBD) of the S protein produced in CHO-K1 cells as a protein component. The immunogenicity of the developed combined vaccine and its individual components was compared and the contribution of each component to the induction of the immune response was analyzed. The combined DNA/protein vaccine possesses the advantages of both underlying approaches and is capable of inducing both humoral (similar to subunit vaccines) and cellular (similar to DNA vaccines) immunity.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811049 | PMC |
| http://dx.doi.org/10.1007/s10517-023-05682-9 | DOI Listing |
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