Cyclam-picolinate chelators were functionalized click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-radiocomplexes. The -aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.
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| http://dx.doi.org/10.1039/d2cc06602e | DOI Listing |
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