Chemical constituents from the stem bark of and their SREBP-1c inhibitory activity.

J Asian Nat Prod Res

Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.

Published: September 2023

One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of . The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid () and 3--methylfisetin () showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.

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http://dx.doi.org/10.1080/10286020.2022.2163633DOI Listing

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