AI Article Synopsis
- Glutathione-responsive nanogels (CDNPs) were created using a crosslinker and combined with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib.
- These nanogels effectively trigger pyroptosis in tumor cells, boosting the body's antitumor immune response.
- When used alongside the αPD-1 antibody, CDNPs significantly reduced tumor growth and extended survival in a melanoma mouse model.
Article Abstract
Glutathione-responsive nanogels (CDNPs) crosslinked crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with αPD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.
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| http://dx.doi.org/10.1039/d2cc05498a | DOI Listing |
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