Tissue-resident memory T (T ) cells play a vital role in local immune protection against infection and cancer. The location of T cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next-generation vaccines. Here, we discuss differential requirements for CD8 T cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue-derived factors, local antigen, and adjuvants on T cell generation in the context of vaccination.
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