Two fungi, and were cultured under different conditions to obtain fourteen compounds. The axenic cultures of and in potato dextrose broth (PDB) medium yielded fusaric acid (), 9,10-dehydrofusaric acid (), and tyrosol, whereas their co-cultivation produced fusarinol (), a fusaric acid complex with magnesium (), 9,10-dehydrofusaric acid complex with magnesium (), and 5-butyl-5-(hydroxymethyl) dihydrofuranone (). Upon changing the medium from PDB to Czapek, different compounds (uracil, -hydroxy acetophenone, and cyclo(L-Leu-L-Pro) were obtained. Fusaric acid () was biotransformed into fusarinol () by , suggesting a detoxification process, and three other compounds were obtained: 7-hydroxyfusarinol (), 9,10-dehydrofusarinol (), and fusarinyl acetate (). Epigenetic modulation of suberohydroxamic acid against afforded gibepyrone B (). These compounds were subjected to a papain inhibition enzymatic assay; the highest inhibitory activity was displayed by the two magnesium complexes, at 56 and 54% inhibition, respectively.
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