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Comparative anti-herpes simplex virus type 1 and chemical profiling of and collected from North Africa. | LitMetric
Herpes simplex virus (HSV) can infect millions of people worldwide causing mild to life-threating infections. The current study demonstrates the first comparative anti-HSV type 1 activity and phytochemical investigation of and collected from Egypt and Libya. Liquid chromatography/mass spectrometry (LC/MS) analysis allowed the identification of 56 and 38 compounds in the Egyptian and Libyan ethanolic extracts, respectively, in addition to 46 and 50 compounds in the Egyptian and Libyan ethanolic extracts, respectively. Gas chromatography/mass spectrometry (GC/MS) analysis of their corresponding essential oils revealed the presence of 15, 17, 17 and 8 compounds in Egyptian and Libyan and respectively. The major chemical classes of the identified compounds were phenolic acids, flavonoids and oxygenated monoterpenes. Evaluation of the anti-HSV1 activities of the studied extracts showed that the Egyptian ethanolic extracts were the most potent extract with more than 200-fold reduction in the viral PFU.
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chromatography/mass spectrometry
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