Biosimilars (BS) are promoted worldwide because of the high cost of biologics. However, patients are apprehensive about switching to BS. For some diseases, several factors, which may be disease-dependent, influence patients' acceptance of switching to BS. Herein, we evaluated whether factors influencing acceptance for switching were disease-dependent among Japanese patients with different diseases. This cross-sectional study involved pharmacists' interviews with patients who used or planned to use biologics. Demographic and clinical characteristics were retrospectively investigated using the patients' medical records. Multivariate logistic regression showed that switch refusal was associated with a history of adverse reactions to biologics (odds ratio [95% confidence interval (CI)] = 3.38 [1.35-8.44]), history of complaints related to disease activity (3.57 [1.53-8.32]), and unacceptability of generic drugs (7.62 [2.70-21.60]). Subgroup analyses suggested that the unacceptability of generic drugs was a common factor, regardless of the disease. Concomitantly, histories of adverse reactions to biologics and complaints related to disease activity were disease-dependent factors. Healthcare professionals should help patients in selecting BS, considering these factors according to the disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/bpb.b22-00429 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Colorimetric Detection of Naphthalene Enabled by Intra- to Intermolecular Charge Transfer Interplay Induced by π-hole···π Interactions of a TPA-Attached Pyrazinacene.
Chemistry
January 2025
Shibaura Institute of Technology: Shibaura Kogyo Daigaku, Applied Chemistry, Fukasaku 307, Minuma-ku, 337-8570, Saitama, JAPAN.
A new Donor-Acceptor type pyrazinacene derivative (1) featuring strong ICT was synthesized by linking electron-donating triphenylamine (TPA) and electron-accepting CN groups via a pyrazinacene core. The compound exhibits a dramatic color change from greenish blue to red-violet upon selective recognition of naphthalene (3) to form a 1:1 co-crystal (1•3). This color change is induced by intermolecular CT between pyrazinacene and naphthalene's aromatic moieties, driven by π-hole···π interactions.
View Article and Find Full Text PDFPerformance and Energy Consumption Analysis for UWSNs with Priority Scheduling Based on Access Probability and Wakeup Threshold.
Sensors (Basel)
January 2025
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
As advancements in autonomous underwater vehicle (AUV) technology unfold, the role of underwater wireless sensor networks (UWSNs) is becoming increasingly pivotal. However, the high energy consumption in these networks can significantly reduce their operational lifespan, while latency issues can impair overall network performance. To address these challenges, a novel mixed packet forwarding strategy is developed, which incorporates a wakeup threshold and a dynamically adjusted access probability for the cluster head (CH).
View Article and Find Full Text PDFAssessment of physical education teachers' use of distance teaching behavior under the influence of the COVID-19 pandemic.
PeerJ
January 2025
Department of Physical Education, Health & Recreation, National Chiayi University, Chiayi, Taiwan.
Background: For many physical education teachers, being suddenly forced to switch from traditional face-to-face teaching to online teaching without adequate mental preparation posed numerous challenges and difficulties. Therefore, the purpose of this study is to validate the use of distance teaching behavior models for physical education teachers under the influence of the COVID-19 pandemic.
Method: The unified theory of acceptance and use of technology (UTAUT) model was employed to explore the use intention and use behavior of distance teaching.
Support for and likely impacts of endgame measures in the Smokefree Aotearoa Action Plan: findings from the 2020-2021 International Tobacco Control New Zealand (EASE) surveys.
N Z Med J
January 2025
Professor, Department of Public Health, University of Otago Wellington, Wellington.
Aim: In February 2024, the Aotearoa New Zealand Government repealed legislation to mandate very low nicotine cigarettes (VLNCs), greatly reduce the number of tobacco retailers and disallow sale of tobacco products to people born after 2008 (smokefree generation). We investigated acceptability and likely impacts of these measures among people who smoke or who recently (≤2 years) quit smoking.
Method: We analysed data from 1,230 participants from Wave 3 (conducted in late 2020 and early 2021) and 615 participants from Wave 3.
Safety of tenecteplase vs. alteplase in telestroke: a large multistate experience (STAT).
Front Neurol
January 2025
TeleSpecialists, LLC, Fort Myers, FL, United States.
Introduction: Prompt treatment with IV thrombolytics (IVT) in acute ischemic stroke (AIS) patients is critical for improved recovery and survival. Recently, hospital systems have switched to the IVT tenecteplase (TNK) instead of the FDA-approved alteplase (tPA) for treatment. Multiple studies and meta-analyses evaluating the efficacy and safety of TNK demonstrate similar or superior outcomes when compared to tPA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!