Dichotomous activity and function of neurons with low- and high-frequency discharge in the external globus pallidus of non-human primates.

Cell Rep

Department of Medical Neuroscience, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem 91904, Israel; Department of Neurosurgery, Hadassah Medical Center, Jerusalem 91120, Israel.

Published: January 2023

AI Article Synopsis

  • The study investigates two types of neurons in the non-human primate external globus pallidus: low-frequency discharge (LFD) and high-frequency discharge (HFD) neurons, highlighting a gap in previous research that often overlooked LFD neurons.
  • It found that LFD neurons showed burst activity, were linked to the importance of behavioral cues, and had correlated spiking activity, while HFD neurons were more likely to pause and focused on cue value with uncorrelated spiking.
  • These results suggest a complex organization in the external globus pallidus that plays a crucial role in the normal functioning of the basal ganglia.

Article Abstract

To date, there is a consensus that there are at least two neuronal populations in the non-human primate (NHP) external globus pallidus (GPe): low-frequency discharge (LFD) and high-frequency discharge (HFD) neurons. Nevertheless, almost all NHP physiological studies have neglected the functional importance of LFD neurons. This study examined the discharge features of these two GPe neuronal subpopulations recorded in four NHPs engaged in a classical conditioning task with cues predicting reward, neutral and aversive outcomes. The results show that LFD neurons tended to burst, encoded the salience of behavioral cues, and exhibited correlated spiking activity. By contrast, the HFD neurons tended to pause, encoded cue valence, and exhibited uncorrelated spiking activity. Overall, these findings point to the dichotomic organization of the NHP GPe, which is likely to be critical to the implementation of normal basal ganglia functions and computations.

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Source
http://dx.doi.org/10.1016/j.celrep.2022.111898DOI Listing

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