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Cell-specific effects of the sole C. elegans Daughterless/E protein homolog, HLH-2, on nervous system development. | LitMetric

AI Article Synopsis

  • Researchers examined the role of proneural class I/II bHLH complexes in neurogenesis across the entire nervous system of Caenorhabditis elegans.
  • They genetically removed the hlh-2 gene to disrupt all proneural bHLH complexes, observing widespread impacts on neurogenesis, yet still noting normal neuron production in several lineages.
  • The study concludes that while proneural bHLH complexes are important for neurogenesis, their influence varies depending on the specific lineage, cell type, and differentiation processes involved.

Article Abstract

Are there common mechanisms of neurogenesis used throughout an entire nervous system? We explored to what extent canonical proneural class I/II bHLH complexes are responsible for neurogenesis throughout the entire Caenorhabditis elegans nervous system. Distinct, lineage-specific proneural class II bHLH factors are generally thought to operate via interaction with a common, class I bHLH subunit, encoded by Daughterless in flies, the E proteins in vertebrates and HLH-2 in C. elegans. To eliminate function of all proneuronal class I/II bHLH complexes, we therefore genetically removed maternal and zygotic hlh-2 gene activity. We observed broad effects on neurogenesis, but still detected normal neurogenesis in many distinct neuron-producing lineages of the central and peripheral nervous system. Moreover, we found that hlh-2 selectively affects some aspects of neuron differentiation while leaving others unaffected. Although our studies confirm the function of proneuronal class I/II bHLH complexes in many different lineages throughout a nervous system, we conclude that their function is not universal, but rather restricted by lineage, cell type and components of differentiation programs affected.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108603PMC
http://dx.doi.org/10.1242/dev.201366DOI Listing

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