Cities' transition from fossil-based systems of energy production and consumption to renewable energy sources-the energy transition-is critical to mitigating climate change impact as cities' energy consumption and CO emissions account for two-thirds and over 70% of the world's total, respectively. Given cities' heterogeneity, they need specific low-carbon roadmaps instead of one-size-fits-all approaches. Here, we used an Energy Transition Index (ETI) to characterize the city-level energy transitions from energy system performance and transition readiness dimensions. The ETI scores for 282 cities in China revealed a significant heterogeneity across cities and over time, and the gap between the cities in the top and bottom quartiles was persistent. We estimated that China's energy and carbon intensity could decrease by 34% and 32%, respectively, and that carbon per capita could fall by 17% if each city modestly follows the sustainable development path forged by the best performing cities with similar economic structures.
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http://dx.doi.org/10.1016/j.isci.2022.105803 | DOI Listing |
J Transl Med
December 2024
Department of Blood Transfusion, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity.
View Article and Find Full Text PDFJ Transl Med
December 2024
Tongji Medical College, Maternal and Child Health Hospital of Hubei Province, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430070, China.
Background: As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal. Previous studies have shown that tumor progression is closely related with tumor metabolism and microenvironment reshaping, with disruptions in energy metabolism playing a critical role in this process. To delve deeper into the understanding of CSCC development, our research focused on analyzing the tumor microenvironment and metabolic characteristics across different regions of tumor tissue.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Precious metal-based single-atom catalysts (PM-SACs) hosted in N-doped carbon supports have shown new opportunities to revolutionize cathodic oxygen reduction reaction (ORR). However, stabilizing the high density of PM-N sites remains a challenge, primarily due to the inherently high free energy of isolated metal atoms, predisposing them to facile atomic agglomeration. Herein, a molten salt-assisted synthesis strategy is proposed to prepare porous PM/N-C (PM = Ru, Pt, and Pd) electrocatalysts with densely accessible PM-N sites.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Medical Engineering and Biotechnology, Ernst-Abbe-Hochschule, University of Applied Sciences, Carl-Zeiss-Promenade 2, 07745, Jena, Germany.
Cultivating insect cells in glass vessels can be challenging. Due to uncontrolled cell adhesion and associated cell loss as well as clumping, the replication of experiments is put at risk. A cost-effective solution to improve and stabilize cultivation may be to silanize glass vessels, making them more hydrophobic and chemically inert.
View Article and Find Full Text PDFCommun Chem
December 2024
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
The PepT transporter mediates the transport of peptides across biological membranes. Despite advancements in structural biology, including cryogenic electron microscopy structures resolving PepT in different states, the molecular basis of peptide recognition and transport by PepT is not fully elucidated. In this study, we used molecular dynamics simulations, Markov State Models (MSMs), and Transition Path Theory (TPT) to investigate the transport mechanism of an alanine-alanine peptide (Ala-Ala) through the PepT transporter.
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