Background: Necrotizing fasciitis is a life-threatening and potentially fatal condition which commonly affects extremities, abdominal wall and perineum. However, it can affect any body part. Breasts are very rarely affected, with most of the cases are following surgical intervention or trauma. Predisposing conditions include diabetes, chronic alcoholism, advanced age, vascular disease, and immunosuppression and many cases are preceded by an injury or invasive procedure. Here we present necrotizing fasciitis of the breast in a 28-year-old female patient with no identified risk factor.
Clinical Presentation: A 28-year-old woman on her 4th month of lactation presented to the emergency department with a 4-day history of right breast pain and swelling. Associated with this, she had darkening of the skin of the right breast, high-grade fever, and foul-smelling discharge from the wound. On examination, she was febrile, tachycardic and hypotensive. Breast examination showed signs suggestive of NF. Subsequently, the patient was managed with broad spectrum antibiotics, supportive care, surgical debridement followed by partial mastectomy and finally the patient was discharged improved.
Conclusion: Although it is a rare phenomenon, necrotizing soft-tissue infections of the breast can progress rapidly and carry a high mortality rate. Therefore, early diagnosis and immediate surgical intervention are of paramount importance. Here, we aim to show the importance of early diagnosis and the need for appropriate therapy to avoid complications and death.
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http://dx.doi.org/10.1016/j.ijscr.2022.107844 | DOI Listing |
J Inflamm Res
January 2025
Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Purpose: Necrotizing fasciitis (NF) is a scarce but potentially life-threatening infection. However, no research has reported the cellular heterogeneity in patients with NF. We aim to investigate the change of cells from deep fascia in response to NF by single-cell RNA-seq.
View Article and Find Full Text PDFObjective: Periorbital necrotizing soft tissue infection (NSTI) is a rare entity caused either by polymicrobial infection (type 1) or Streptococcus pyogenes and/or Staphylococcus species (type 2). A high level of clinical suspicion is necessary to make the diagnosis. We present 3 cases of NSTI illustrating our diagnostic and therapeutic approach.
View Article and Find Full Text PDFMicroorganisms
January 2025
Emergency, Anesthesiological and Reanimation Sciences Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS of Rome, 00168 Rome, Italy.
() is a Gram-negative, halophilic bacillus known for causing severe infections such as gastroenteritis, necrotizing fasciitis, and septic shock, with mortality rates exceeding 50% in high-risk individuals. Transmission occurs primarily through the consumption of contaminated seafood, exposure of open wounds to infected water, or, in rare cases, insect bites. The bacterium thrives in warm, brackish waters with high salinity levels, and its prevalence is rising due to the effects of climate change, including warming ocean temperatures and expanding coastal habitats.
View Article and Find Full Text PDFActa Ortop Mex
January 2025
Department of Orthopedic and Trauma Surgery, Hospital Quironsalud Badalona. Barcelona, Spain.
Introduction: necrotizing fasciitis (NF) is a rare soft tissue infection that leads to sepsis and death without an early surgical treatment. LRINEC (laboratory risk indicator for necrotizing fasciitis) scale is one of the most accepted tests for diagnosis. This study presents a retrospective evaluation of the usefulness of the LRINEC scale in the diagnosis and prognosis of NF.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Department of Surgery, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka. Electronic address:
Introduction: Necrotizing fasciitis (NF) is a rapidly progressive life-threatening infection involving necrosis of subcutaneous tissues and fascia. Though it mainly affects the extremities, perineum and abdominal wall, it rarely affects the breast.
Presentation Of Case: A 30-year-old woman on postpartum day seven presented with one-day history of fever with chills and rigors and painful, swollen and tender left breast.
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