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| http://dx.doi.org/10.34067/KID.0004952022 | DOI Listing |
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Endocan, a novel glycoprotein with multiple biological activities, may play important roles in neurological diseases.
Front Aging Neurosci
September 2024
Department of Neurology, Shengjing Hospital of China Medical University, China Medical University, Shenyang, China.
Article Synopsis
- Endothelial cell specific-1 (endocan) is a soluble protein secreted by endothelial cells, linked to cancer development, cardiovascular issues, autoimmune diseases, and sepsis.
- Its biological functions depend on specific regions in its structure, with elevated levels indicating endothelial activation and dysfunction.
- The review explores endocan's structure, functions, and potential clinical significance in neurological disorders.
Engineering Lymphangiogenesis-On-Chip: The Independent and Cooperative Regulation by Biochemical Factors, Gradients, and Interstitial Fluid Flow.
Adv Biol (Weinh)
April 2024
Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, 77843, USA.
Despite the crucial role of lymphangiogenesis during development and in several diseases with implications for tissue regeneration, immunity, and cancer, there are significantly fewer tools to understand this process relative to angiogenesis. While there has been a major surge in modeling angiogenesis with microphysiological systems, they have not been rigorously optimized or standardized to enable the recreation of the dynamics of lymphangiogenesis. Here, a Lymphangiogenesis-Chip (L-Chip) is engineered, within which new sprouts form and mature depending upon the imposition of interstitial flow, growth factor gradients, and pre-conditioning of endothelial cells with growth factors.
View Article and Find Full Text PDFCerium oxide nanoparticles impact on sepsis-induced cerebral injury: Deciphering miRNA / NF-κB/TLR signalling pathway.
Cell Mol Biol (Noisy-le-grand)
January 2024
Department of Narcotics, Ergogenics and Poisons, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
Sepsis is regarded as an inflammatory syndrome that consists of complex biochemical and pathophysiological dysregulation, brought on by endogenous factors in response to systemic infection. Sepsis can cause short- and long-term cerebral injury. Cerium oxide nanoparticles (CeO2 NPs) have been reported to possess both anti-inflammatory and antioxidative properties.
View Article and Find Full Text PDFEndothelial cell-specific molecule 1 is regulated separately in follicular and serum compartments of PCOS patients: a pilot study.
Eur Rev Med Pharmacol Sci
October 2023
Operating Room Services Department, Nisantası University, Vocational School, Istanbul, Turkey.
Objective: The aim of our study is to detect endothelial cell-specific molecule 1 (ESM-1) levels in the serum and follicular fluids (FF) of patients undergoing IVF/ICSI for PCOS. The presence of ESM-1 traffic between the serum and follicular compartment was analyzed.
Patients And Methods: A total of 50 patients, including 25 infertile patients diagnosed with PCOS according to the Revised Rotterdam criteria, and 25 patients in infertility follow-up for reasons other than PCOS, were included in the pilot study.
Investigation of Serum Endocan Levels and Age in Critical Inflammatory Conditions.
Int J Mol Sci
June 2023
First Department of Critical Care Medicine & Pulmonary Services, Medical School, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece.
Article Synopsis
- Aging negatively impacts the endothelium, which is critical for vascular health, and the study focuses on endocan (ESM-1), a protein linked to endothelial function in critically ill patients.
- ESM-1 levels were found to be significantly higher in critically ill COVID-19 patients compared to non-septic and septic patients, and older septic patients had higher levels of ESM-1 compared to younger ones.
- The research revealed that while ESM-1 is a potential prognostic biomarker, its effectiveness varies with age and the degree of endothelial dysfunction, particularly in the younger septic patient demographic.
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