() is a clinical multidrug-resistant pathogen causing life-threatening infection, which makes it important to discover antibacterial agents with novel scaffolds and unique mechanism. In this study, the diarylurea scaffold was found to have potent antibacterial effect on . Diarylurea with benign drug-like property exhibited potent antibacterial and anti-biofilm activity through inhibiting the genes expression of NlpC/p60 hydrolase-secreted antigen A () and autolysins (), down-regulating the expression of biofilm adherence related genes aggregation substance (), enterococcal surface protein () against . Moreover, can be docked into SagA to inhibit daughter cell separation. In a mouse model of abdominal infection, decreased the bacterial load and the level of IL-6 and TNF-α in a time-dependent manner. Overall, these findings indicated that diarylurea has the potential to be developed as a therapeutic agent to treat drug-resistant enterococci and biofilm-related infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797508 | PMC |
| http://dx.doi.org/10.3389/fmicb.2022.1071255 | DOI Listing |
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