In this paper, we consider the problem of estimating the log-normal coefficients of variation when multiple samples from log-normal populations with unequal variances are combined. We suggest some efficient estimation methods based on pretest and JamesStein procedures. In a large-sample setup, we propose a test statistic (pretest) for testing the homogeneity assumption of log-normal coefficients of variation. Under a class of local alternatives, we obtain some asymptotic distributions to make fair comparisons of the suggested estimators based on asymptotic quadratic bias and risk. In addition, we conduct a Monte-Carlo simulation study to validate the relative efficiency performance of the proposed estimators when the homogeneity hypothesis may or may not hold. Unlike the pooled estimate of common coefficient of variation, the results show that James-Stein estimators behave robustly against departures from the homogeneity hypothesis and have bounded quadratic bias and risk. The results also show that the pretest estimators perform efficiently in a significant portion of the parameter space. Historical weather data is used to in the application of the proposed estimators.
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http://dx.doi.org/10.1016/j.mex.2022.101939 | DOI Listing |
Macromol Rapid Commun
December 2024
Institute of Chemical Technology and Polymer Chemistry, Karlsruhe Institute of Technology (KIT), Engesserstraße 18, 76131, Karlsruhe, Germany.
The determination of molar masses and their distributions is crucial in polymer synthesis and design. This work presents the current performance and limitations of diffusion-ordered spectroscopy (DOSY) on a low-field (benchtop) NMR spectrometer (at 90 MHz) as an alternative to size exclusion chromatography (SEC) for determining diffusion coefficient distributions (DCDs) and molar mass distributions (MMDs). After optimization for narrowly distributed homopolymers, MMDs obtained with inverse Laplace transformation (ILT) and log-normal distribution are compared with average molar masses obtained with mono- and bi-exponential fits, as well as MMDs obtained from SEC.
View Article and Find Full Text PDFCurr Drug Deliv
November 2024
School of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh 173229, India.
Background: The therapeutic effect of NS oil in mild to moderate psoriasis is limited owing to low play load of thymoquinone (<15 %w/w), irritation, dripping, low viscosity and thus, less contact time on the lesions.
Aims: This study aimed at developing and characterizing the ethanolic vesicular hydrogel system of Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-psoriatic activity.
Objective: The objective of this study was to develop NS EV hydrogel and evaluate its anti-psoriatic activity.
Phys Rev Lett
June 2024
Department of Physics and Astronomy, University of California Riverside, Riverside, California 92521, USA.
We make forecasts for the constraining power of the 1D wavelet scattering transform when used with a Lyman-α forest cosmology survey. Using mock simulations and a Fisher matrix, we show that there is considerable cosmological information in the scattering transform coefficients not captured by the flux power spectrum. We estimate mock covariance matrices assuming uncorrelated Gaussian pixel noise for each quasar at a level drawn from a simple log-normal model.
View Article and Find Full Text PDFJ Med Syst
June 2024
Departments of Anesthesia and Health Management & Policy, University of Iowa, 6 JCP, Iowa City, Iowa, IA, 52246, USA.
Modern anesthetic drugs ensure the efficacy of general anesthesia. Goals include reducing variability in surgical, tracheal extubation, post-anesthesia care unit, or intraoperative response recovery times. Generalized confidence intervals based on the log-normal distribution compare variability between groups, specifically ratios of standard deviations.
View Article and Find Full Text PDFBackground: Prosthetic joint infections (PJIs) are a serious negative outcome of arthroplasty with incidence of about 1%. Risk of PJI could depend on local treatment policies and guidelines; no UK-specific risk scoring is currently available.
Objective: To determine a risk quantification model for the development of PJI using electronic health records.
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