Introduction: Phytochemicals present in () leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.
Methods: Phytochemical and antioxidant potential of leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.
Results And Discussions: The toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the treated group in comparison to positive control (hepatotoxic rats). leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.
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| http://dx.doi.org/10.3389/fnut.2022.1078896 | DOI Listing |
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