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Intraventricular conduction disturbances (IVCD) are currently generally accepted as ECG diagnostic categories. They are characterized by defined QRS complex patterns that reflect the abnormalities in the intraventricular sequence of activation that can be caused by pathology in the His-Purkinje conduction system (HP) or ventricular myocardium. However, the current understanding of the IVCD's underlying mechanism is mostly attributed to HP structural or functional alterations. The involvement of the working ventricular myocardium is only marginally mentioned or not considered. This opinion paper is focused on the alterations of the ventricular working myocardium leading to the most frequent IVCD pattern-the left bundle branch block pattern (LBBB). Recognizing the underlying mechanisms of the LBBB patterns and the involvement of the ventricular working myocardium is of utmost clinical importance, considering a patient's prognosis and indication for cardiac resynchronization therapy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800102 | PMC |
http://dx.doi.org/10.1155/2022/3438603 | DOI Listing |
J Am Heart Assoc
December 2024
Graduate Program in Translational Biology Medicine and Health, Virginia Tech Roanoke VA USA.
Background: Previous studies suggest the relationship between activation time (AT) and action potential duration (APD) in the heart is dependent on electrotonic coupling, but this has not been directly tested. This study assessed whether acute changes in electrical coupling, or other determinants of conduction or repolarization, modulate APD heterogeneity.
Methods And Results: Langendorff-perfused guinea pig hearts were epicardially paced and optically mapped after treatment with the gap junction uncoupler carbenoxolone, ephaptic uncoupler mannitol, ephaptic enhancer dextran 2MDa, sodium channel inhibitor flecainide, or rapid component of the delayed rectifier potassium channel inhibitor E4031.
ARYA Atheroscler
January 2024
Department of Cardiology, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Percutaneous coronary intervention (PCI) is an effective treatment for coronary artery disease. Previous studies have demonstrated the delayed effects of PCI on left ventricular diastolic and systolic function. However, the early impact on these parameters has not been systematically examined.
View Article and Find Full Text PDFInt J Cardiol
December 2024
Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev & Gentofte Hospital, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Denmark; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Herlev, Denmark.
Background: Cardiac power (CP) integrates echocardiographic and clinical parameters of hemodynamics, yet its prognostic value within the general population remains unexplored. This study investigated the association between CP and incident heart failure (HF) and cardiovascular (CV) death in the general population.
Methods: In this prospective cohort study, we measured CP in a total of 4022 individuals from the general population without prior HF.
Biol Pharm Bull
December 2024
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University.
The effect of a citrus-derived flavonoid, hesperetin, on the automaticity and contraction of isolated guinea pig myocardium was examined. Hesperetin inhibited the rate of ectopic action potential firing of the pulmonary vein myocardium; the slope of the diastolic depolarization was decreased with minimum change in the action potential waveform. The effect was dependent on the concentration; the EC value for firing rate was 56.
View Article and Find Full Text PDFClin Imaging
December 2024
Department of Radiology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 12 Changjia Lane, Alarm Bell St, Fucheng District, Mianyang 621000, China. Electronic address:
Purpose: To investigate differences in left ventricular wall thickness (LVWT) measurements between end-diastole and mid-diastole using cardiac computed tomography (CCT) and establish LVWT reference values stratified by phase, sex, and region.
Methods: Subjects who underwent CCT without a history of cardiovascular disease or risk factors were retrospectively included between 2021 and 2024. LVWT was manually measured in each segment according to the American Heart Association's 17-segment model at end-diastole and mid-diastole.
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