AI Article Synopsis
- Pericardial effusions in dogs are commonly noted, but their link to rodenticide poisoning is not well documented.
- A mixed-breed dog showed signs of illness, including anorexia and cough, with diagnostic imaging revealing significant heart enlargement and fluid accumulation around the heart.
- Treatment with vitamin K led to a complete recovery, marking the first documented case of severe pericardial issues related to anticoagulant exposure in dogs.
Article Abstract
Background: Pericardial effusions are well described in dogs; however, their association with rodenticide intoxication in the canine population is not widely described.
Case Description: An adult mixed-breed dog was presented for 1-day history of anorexia and cough. Thoracic radiographs revealed moderate generalized cardiomegaly with globoid-shaped cardiac silhouette and mild bilateral pleural effusion. Echocardiography showed mild tamponating pericardial effusion and diffuse severe thickened pericardium. Compete blood count and blood chemistry at presentation were not specific. A coagulation profile was completed and showed severe prolongation of prothrombin time and partial thromboplastin time. Intravenous therapy with vitamin K was started at 5 mg/kg BID and on follow-up echocardiography performed 12 hours later there was evidence of complete regression of the pericardial thickening and pericardial effusion.
Conclusion: To the authors' knowledge, this is the first case report describing severe pericardial thickening, constrictive pericarditis, and cardiac tamponade secondary to spontaneous anticoagulant-induced hemopericardium in dogs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789774 | PMC |
| http://dx.doi.org/10.5455/OVJ.2022.v12.i5.18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Mysterious Cause of Coagulopathy With Bleeding Diathesis.
Cureus
December 2024
Department of Internal Medicine IV, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Vitamin K is essential to produce functional vitamin K-dependent coagulation factors (prothrombin, factors VII, IX, and X). Vitamin K antagonists inhibit the normal activation of these factors, leading to bleeding manifestations of variable severity. Long-acting vitamin K antagonists or superwarfarins were developed as rodenticides and have a significantly longer half-life and greater potency when compared to warfarin.
View Article and Find Full Text PDFWidespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.
Sci Rep
January 2025
Czech Agrifood Research Center, Drnovska 507/73, CZ-16100, Prague 6, Czech Republic.
Despite the widespread use of anticoagulant rodenticides in baits for controlling commensal rodent pests, their application is problematic due to secondary intoxication and increasing resistance. In contrast to studies on Western European house mice (Mus musculus domesticus), few resistance studies have focused on Eastern European house mice (M. musculus musculus), which have a western distribution boundary in the Czech Republic.
View Article and Find Full Text PDFCauses of Death and Screening for Toxicants and Hemopathogens of European Hedgehogs (Erinaceus europaeus) from a Wildlife Rehabilitation Center in Northern France.
J Wildl Dis
January 2025
Pôle EVAAS, VetAgro Sup, 1 avenue Bourgelat, Marcy l'Etoile 69280, France.
Article Synopsis
- The European hedgehog is declining in population, prompting conservation efforts, and this study focused on understanding the causes of death in hedgehogs admitted to a French rehabilitation center.
- Out of 159 dead hedgehogs analyzed, 92% had identifiable causes of death, with impaired condition (30%), bacterial infections (26%), and trauma (20%) being the most common.
- The study also found significant exposure to toxicants, such as anticoagulant rodenticides in 42% of hedgehogs, alongside a low prevalence of blood pathogens, emphasizing the need for further investigations into the health and ecological factors affecting hedgehog populations.
First evidence of the suitability of hair for assessing wildlife exposure to anticoagulant rodenticides (ARs).
Environ Res
January 2025
Department of Environmental Sciences, Informatic, And Statistics, Ca' Foscari university Venice, Via Torino 155, 30172 Venezia-Mestre, Italy; Società Estense Servizi Ambientali (S.E.S.A. S.p.A.), 35042 EsteItaly.
Article Synopsis
- - Anticoagulant rodenticides (ARs) are pesticides that can cause severe bleeding in rodents by inhibiting vitamin K function; their non-selective nature poses risks to wildlife, leading to potential exposure through various pathways including direct ingestion and secondary predation on affected rodents.
- - The study focused on the Red fox in Northern Italy and used hair samples to investigate AR exposure, specifically analyzing both first-generation (FGARs) and second-generation (SGARs) anticoagulants.
- - Results showed that half of the fox hair samples contained ARs, with a notable prevalence of SGARs like brodifacoum, indicating a significant exposure risk for these animals, and demonstrating that hair can serve as an effective
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!