Context: The proto-oncogene was discovered at the chromosomal breakpoint of t (14;18) found in follicular lymphoma. Histological changes in dysplasia are considered the earliest signs preceding the progression into squamous cell carcinoma. Serving as critical regulators of apoptotic pathways, prohibits programmed cell death and subsequently assists in uncontrolled neoplastic growth.
Settings And Design: This study included 48 cases, eight each of epithelial dysplasia and squamous cell carcinoma. Immunohistochemical staining using antibody was performed and different histological parameters were correlated with positive cells in all the cases.
Materials And Methods: All 3 m thick sections were stained with antibody. After identifying four representative fields at 40x, their images were obtained for assessment of labelled cells and their intensity along with different histological parameters in all the cases.
Statistical Analysis: The differences between different histological parameters were analysed using the Anova test, post hoc test and Bonferroni test. Pearson's Chi-square test was carried out to determine the level of correlation between the positive cells in both epithelial dysplasia and oral squamous cell carcinoma cases.
Conclusion: Sequential increase in the bcl-2 expression was observed in increasing grades of epithelial dysplasia, whereas bcl-2 expression was significantly decreased in ascending stages of squamous cell carcinoma thus, suggesting a possible role of bcl-2 in disease progression from premalignancy to malignancy.
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| http://dx.doi.org/10.4103/jomfp.jomfp_326_21 | DOI Listing |
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