Spacing out dual checkpoint inhibition improves antigen-specific T cell manufacture.

Mol Ther Methods Clin Dev

Department of Immuno-oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

Published: March 2023

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772500PMC
http://dx.doi.org/10.1016/j.omtm.2022.11.007DOI Listing

Publication Analysis

Top Keywords

spacing dual
4
dual checkpoint
4
checkpoint inhibition
4
inhibition improves
4
improves antigen-specific
4
antigen-specific t cell
4
t cell manufacture
4
spacing
1
checkpoint
1
inhibition
1

Similar Publications

Background/aim: Angiogenesis imaging has been a valuable complement to metabolic imaging with 2-deoxy-2-[F]fluoroglucose (FDG). In our longitudinal study, we investigated the tumour heterogeneity and the relationship between FDG and [Ga]Ga-NODAGA-c(RGDfK) (RGD) accumulation in breast cancer xenografts.

Materials And Methods: Two groups of cell lines, a fast-growing (4T1) and a slow-growing cell line (MDA-MB-HER2+), were inoculated into SCID mice.

View Article and Find Full Text PDF

Determinants of physical activity adoption and maintenance in older adults: A dual process approach.

Psychol Sport Exerc

December 2024

School of Health and Human Sciences, University of North Carolina Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA. Electronic address:

Background: Dual process models represent a useful framework for explaining physical activity (PA) in that behavior is explained by reflective (i.e., conscious, effortful) and automatic (i.

View Article and Find Full Text PDF

Polarization-Insensitive Metasurface with High-Gain Large-Angle Beam Deflection.

Materials (Basel)

November 2024

State Key Laboratory of Extreme Photonics and Instrumentation, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 310027, China.

Article Synopsis
  • Metasurfaces can enhance and redirect signals efficiently and cost-effectively, addressing issues like low transmission power in high-frequency communication.
  • This paper introduces a novel metasurface that combines Fabry-Perot cavity theory with a Phase Gradient Partially Reflective Metasurface (PGPRM), featuring a thin, fishnet structure.
  • The proposed design allows for significant beam deflection (up to 47°) and high gain (up to 16.9 dBi) in the 8.6-9.2 GHz frequency range, making it ideal for improving indoor wireless communication.
View Article and Find Full Text PDF

Ultrasonic-assisted MoS/GO/TiO ceramic coatings: Enhancing anti-friction performance through dual-interface optimization.

Ultrason Sonochem

November 2024

College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, PR China. Electronic address:

Ceramic coatings containing two-dimensional materials (2D materials) provide effective protection for light alloys during wear, significantly improving their anti-friction performance. MoS has proven highly effective in enhancing the anti-friction performance of ceramic coatings, particularly when synthesized via plasma electrolytic oxidation (PEO). However, dislocation pinning due to the incoherent interfaces in MoS/TiO coatings tends to cause localized stress concentrations and brittle fracture, requiring effectively improve nanomechanical properties by optimizing interface design.

View Article and Find Full Text PDF

Demultiplexing-free ultra-compact WDM-compatible multimode optical switch assisted by mode exchanger.

Nanophotonics

August 2024

Key Laboratory of Optoelectronic Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, China.

Silicon-based optical switches are integral to on-chip optical interconnects, and mode-division multiplexing (MDM) technology has enabled modes to function as carriers in routing, further boosting optical switches' link capacity. However, traditional multimode optical switches, which typically use Mach-Zehnder interferometer (MZI) structures and mode (de)multiplexers, are complex and occupy significant physical space. In this paper, we propose and experimentally demonstrate a novel demultiplexing-free dual-mode 3 × 3 thermal-optical switch based on micro-rings (MRs) and mode exchangers (MEs).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!