Department of Biochemistry, BioBoron Research Institute, S.C. Natural Research S.R.L., Podari, Dolj County, Romania;
Published: January 2023
AI Article Synopsis
Article Abstract
Research on the use of boron (B) in the field of oral health has gained momentum in recent years, with various studies on the possibilities of using various B-containing compounds (BCCs). A multitude of applications have been discovered, from cariostatic activity to anti-inflammatory and antifungal activity, paving the way for other new research directions. B is a microelement that is commonly found in the human diet, and present throughout the body, with the highest concentration in the structure of bones, teeth, and gastrointestinal mucus gel layer. Multiple studies have demonstrated that B plays some important roles, especially in bone development and recently has been proposed to have an essential role in the healthy symbiosis. In addition, B has also attracted the interest of researchers, as various studies used BCCs in conventional or modern biomaterials. In this review, we have brought together the information we have found about B updates in the dental field and analyzing its future perspectives and potential for further studies.
Aluminum-doped polycyclic aromatic hydrocarbons (PAHs) are underexplored despite the broad applications of boron-containing PAHs in areas such as catalysis and optoelectronics. We disclose the donor-free, sterically unprotected 9-methyl-9-aluminafluorene (Me-AlFlu; 2), synthesized by heating a 9,9-dimethyl-9-stannafluorene and AlMe in hexanes. The compound is a dimer, (2), with -positioned Al substituents in the solid state.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China.
Inspired by our previous finding that targeting the 150-cavity with a multisite-binding strategy emerged as an effective approach to obtain more potent and selective neuraminidase (NA) inhibitors against influenza virus, we present here the design, synthesis, and optimization of novel boron-containing N-substituted oseltamivir (OSC) derivatives. Exploratory structure-activity relationship (SAR) studies led to the identification of compounds and as the most potent NA inhibitors, surpassing OSC in potency against both wild-type group-1 NAs and oseltamivir-resistant NAs. These compounds demonstrated significant antiviral activity against several wild-type strains and H1N1pdm09 strains (EC = 0.
Both deficiency and toxicity of the micronutrient boron lead to severe reductions in crop yield. Despite this agricultural importance, the molecular basis underlying boron homeostasis in plants remains unclear. To identify molecular players involved in boron homeostasis in maize (Zea mays L.
This study aimed to assess and compare the shielding performance of boron-containing materials for neutrons generated in proton therapy and used in boron neutron capture therapy (BNCT). Five composites, including AlB, Al-BC, Al-TiB, Al-BN, and Al-TiB-BN, were selected as shielding materials, with concrete used as a benchmark. The mass fraction of boron compounds in these materials ranged from 10% to 50%.
An aromatic boron-containing organic compound, CBH, with an unusual CC bond was experimentally synthesized in 2017. Here we investigate the structure and bonding nature of CBH and its derivatives CBR using DFT and VB theory. Although the CC bond in CBR consists of a π bond and a charge-shift (CS) bond, CBF has the lowest LUMO energy and its LUMO is similar to that of ethylene, suggesting that CBF can be an ideal dienophile for the Diels-Alder reaction.
