AI Article Synopsis
- The study focuses on Paris polyphylla var. yunnanensis, a plant used in traditional Chinese medicine, aiming to isolate and identify its bioactive saponins.
- Researchers identified fourteen saponins, including seven new compounds, with Paris saponins VII (PSVII) exhibiting strong cytotoxicity against a specific pancreatic cancer cell line (BxPC-3) at low concentrations.
- Further analysis indicated that PSVII could inhibit cell growth and promote cell death through mechanisms involving apoptosis and pyroptosis by activating specific caspases.
Article Abstract
Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. (Melanthiaceae), an important specie of the genus Paris, has long been in a traditional Chinese medicine (TCM) for a long time. This study aimed to isolate and identify the structures of bioactive saponins from the rhizomes of P. polyphylla var. yunnanensis and evaluate their cytotoxicity against BxPC-3, HepG2, U373 and SGC-7901 carcinoma cell lines. Seven previously undescribed and seven known saponins were identified, and Paris saponins VII (PSVII) showed significant cytotoxicity against the BxPC-3 cell line with IC values of 3.59 μM. Furthermore, flow cytometry, transmission electron microscopy and western-bolt analysis revealed that PSVII inhibited the proliferation of BxPC-3 cells and might be involved in inducing apoptosis and pyroptosis by activating caspase-3, -7 and caspase-1, respectively.
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| http://dx.doi.org/10.1016/j.phytochem.2022.113577 | DOI Listing |
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