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The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers.
J Cancer Res Clin Oncol
January 2025
Sarcoma Unit, Department of Surgery, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Purpose: The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers.
View Article and Find Full Text PDFAdaptable electro-optic detection of THz radiation using a laser-written bull's-eye antenna.
Sci Rep
January 2025
Department of Physics, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
We report a nonlinear terahertz (THz) detection device based on a metallic bull's-eye plasmonic antenna. The antenna, fabricated with femtosecond laser direct writing and deposited on a nonlinear gallium phosphide (GaP) crystal, focuses incoming THz waveforms within the sub-wavelength bull's eye region to locally enhance the THz field. Additionally, the plasmonic structure minimizes diffraction effects allowing a relatively long interaction length between the transmitted THz field and the co-propagating near-infrared gating pulse used in an electro-optic sampling configuration.
View Article and Find Full Text PDFImproved estimation of carbon dioxide and methane using machine learning with satellite observations over the Arabian Peninsula.
Sci Rep
January 2025
Civil and Environmental Engineering Department, Khalifa University, Abu Dhabi, UAE.
Estimating spatiotemporal maps of greenhouse gases (GHGs) is important for understanding climate change and developing mitigation strategies. However, current methods face challenges, including the coarse resolution of numerical models, and gaps in satellite data, making it essential to improve the spatiotemporal estimation of GHGs. This study aims to develop an advanced technique to produce high-fidelity (1 km) maps of CO and CH over the Arabian Peninsula, a highly vulnerable region to climate change.
View Article and Find Full Text PDFDifferential regulatory effects of the N-terminal region in SYK-fusion kinases reveal unique activation-inducible nuclear translocation of ITK-SYK.
Sci Rep
January 2025
Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred Nobels Allé 8, Floor 8, 14152, Huddinge, Sweden.
ITK-SYK and TEL-SYK (also known as ETV6-SYK) are human tumor-causing chimeric proteins containing the kinase region of SYK, and the membrane-targeting, N-terminal, PH-TH domain-doublet of ITK or the dimerizing SAM-PNT domain of TEL, respectively. ITK-SYK causes peripheral T cell lymphoma, while TEL-SYK was reported in myelodysplastic syndrome. BTK is a kinase highly related to ITK and to further delineate the role of the N-terminus, we generated the corresponding fusion-kinase BTK-SYK.
View Article and Find Full Text PDFA New Global Mangrove Height Map with a 12 meter spatial resolution.
Sci Data
January 2025
ETH Zürich, Institut für Umweltingenieurwissenschaften, Zürich, Switzerland.
Mangrove forests thrive along global tropical coasts, acting as a barrier that protects coastlines against storm surges and as nurseries for an entire food web. They are also known for their high carbon sequestration rates and soil carbon stocks. We introduce a new global mangrove canopy height map generated from TanDEM-X spaceborne elevation measurements collected during the 2011-2013 period with a 12-meter spatial resolution and an accuracy of 2.
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