In the last decade, we characterized an enteric neuronal subpopulation of multifunctional mechanosensitive enteric neurons (MEN) while studying the gastrointestinal peristalsis. MEN have been described in a variety of gastrointestinal regions and species. This chapter summarizes existing data on MEN, describing their proportions, firing behaviors, adaptation musters, and chemical phenotypes. We also discuss MEN sensitivity to different mechanical stimulus qualities such as compression and tension along with pharmacology of their responses.
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Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration .
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Department of Surgery, University of Virginia, Charlottesville, VA, United States.
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Piezo2 is a mechanically gated ion channel most commonly expressed by specialized mechanoreceptors, such as the enteroendocrine cells (EECs) of the gastrointestinal epithelium. A subpopulation of EECs expresses Piezo2 and functionally resembles the skin's touch sensors, called Merkel cells. Low-magnitude mechanical stimuli delivered to the mucosal layer are primarily sensed by mechanosensitive EECs in a process we term "gut touch.
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The gastrointestinal (GI) tract is an organ actively involved in mechanical processes, where it detects forces via a mechanosensation mechanism. Mechanosensation relies on specialized cells termed mechanoreceptors, which convert mechanical forces into electrochemical signals via mechanosensors. The mechanosensitive Piezo1 and Piezo2 are widely expressed in various mechanosensitive cells that respond to GI mechanical forces by altering transmembrane ionic currents, such as epithelial cells, enterochromaffin cells, and intrinsic and extrinsic enteric neurons.
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Background: Serving as a reservoir, the gastric fundus can expand significantly, with an initial receptive and a following adaptive relaxation, controlled by extrinsic and intrinsic reflex circuits, respectively. We hypothesize that mechanosensitive enteric neurons (MEN) are involved in the adaptive relaxation, which is initiated when a particular gastric volume and a certain stretch of the stomach wall is reached. To investigate whether the responsiveness of MEN in the gastric fundus is dependent on tissue stretch, we performed mechanical stimulations in stretched versus ganglia "at rest".
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