The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer's disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9803890 | PMC |
| http://dx.doi.org/10.1007/s00210-022-02372-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Study of the Analgesic Activity of the Aqueous and Methanolic Extracts of Fresh Rhizome of Zingiber officinale in Wistar Rats.
Cureus
November 2024
Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Introduction The study was done to evaluate the analgesic activity of the aqueous and methanolic extracts of fresh rhizome of . The study objectives included evaluating and comparing the analgesic activity of both extracts at two different doses with that of the standard drug (aspirin) in Wistar rats using the rat tail-flick method. Method The study was conducted after receiving approval from the animal ethics committee.
View Article and Find Full Text PDF[Prediction of mechanism of ginger-processed Anemarrhenae Rhizoma in intervening in cough due to cold and dampness in lung based on network pharmacology].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Liaoning University of Traditional Chinese Medicine Dalian 116600, China Traditional Chinese Medicine Processing Technology Inheritance Base (Liaoning) of the National Administration of Traditional Chinese Medicine Dalian 116600, China.
This study employed network pharmacology, molecular docking, and animal experiments to investigate the mechanism of ginger-processed Anemarrhenae Rhizoma in treating cough due to cold and dampness in lung, aiming to provide a modern pharmacological basis for this therapy. The active ingredients of ginger-processed Anemarrhenae Rhizoma were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) with the oral bioavailability(OB≥30%) and drug likeness(DL≥0.18) as the screening conditions and from the relevant literature.
View Article and Find Full Text PDFMethyl jasmonate enabled maintained the postharvest flavor quality of ginger (Zingiber officinale roscoe) by reducing the loss of terpene volatile compounds.
Food Chem
December 2024
Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, Hubei, China; Spice Crops Research Institute, College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, Hubei, China; College of Smart Agriculture /Institute of Special Plants, Chongqing University of Arts and Sciences, Yongchuan 402160, Chongqing, China. Electronic address:
Ginger, as a globally vital medicinal and food homologous crop, plays an irreplaceable role in human diet and healthcare. However, during the storage of ginger, the decline of physical properties and degradation of volatile flavor quality have emerged as an industrial concern that severely restricts the market value of the product. MeJA plays an essential role in extending fruit shelf life and regulate the synthesis of volatiles in horticultural products, yet its application in ginger remains unreported.
View Article and Find Full Text PDFMechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Article Synopsis
- Chemotherapy (CT) is a key cancer treatment that uses drugs to eliminate cancer cells, but it can cause harmful side effects that affect patients' quality of life.
- Recent research suggests that CT can induce ferroptosis, a type of cell death linked to iron overload and oxidative stress, in addition to non-ferroptotic side effects like inflammation and mitochondrial dysfunction.
- Natural compounds from ginger, particularly 6-gingerol and zingerone, may help reduce these toxicities, though further studies are needed to clarify their specific effects on ferroptosis linked to chemotherapy.
Distichochlamys genus, belonging to the ginger family, are native to Vietnam and there has not been many research mentioned about biological properties of this genus. In this study, essential oils were extracted from the rhizomes of Distichochlamys benenica (DBEO) and Distichochlamys citrea (DCEO), and the components were identified using gas chromatography-mass spectrometry. Further, for the first time, the anti-inflammatory activity of these essential oils was evaluated in vitro using nitric oxide inhibitory assay and in silico via binding with the inflammatory cyclooxygenase proteins (COX-1 and COX-2).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!