Cu-Catalyzed Methylenation of Alcohols with -Methyl Amide as a Sustainable Methylene Reagent.

J Org Chem

College of Chemistry and Chemical Engineering, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.

Published: January 2023

Herein, we report a new approach to methylenation of alcohols using -methyl amide as a sustainable methylene reagent; the -methyl delivers the methylene group. This new reagent is easily prepared and stable to both air and moisture. Furthermore, the final byproduct of this methylene reagent can be recycled in excellent yields and then reused in methylenation reactions upon treating with CHI.

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http://dx.doi.org/10.1021/acs.joc.2c02637DOI Listing

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