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Technological Adjuncts to Streamline Patient Recruitment, Informed Consent, and Data Management Processes in Clinical Research: Observational Study.
JMIR Form Res
January 2025
Northwestern Medicine, Chicago, IL, United States.
Background: Patient recruitment and data management are laborious, resource-intensive aspects of clinical research that often dictate whether the successful completion of studies is possible. Technological advances present opportunities for streamlining these processes, thus improving completion rates for clinical research studies.
Objective: This paper aims to demonstrate how technological adjuncts can enhance clinical research processes via automation and digital integration.
Evaporating Primordial Black Holes, the String Axiverse, and Hot Dark Radiation.
Phys Rev Lett
December 2024
Univ Coimbra, Faculdade de Ciências e Tecnologia da Universidade de Coimbra and CFisUC, Rua Larga, 3004-516 Coimbra, Portugal.
The search for primordial black holes (PBHs) with masses M≪M_{⊙} is motivated by natural early-Universe production mechanisms and that PBHs can be dark matter. For M≲10^{14} kg, the PBH density is constrained by null searches for their expected Hawking emission (HE), the characteristics of which are, however, sensitive to new states beyond the standard model. If there exists a large number of spin-0 particles in nature, PBHs can, through HE, develop and maintain non-negligible spins, modifying the visible HE.
View Article and Find Full Text PDFTransition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria.
Future Med Chem
January 2025
Department of Biophysics, School of Basic Medical Sciences, Health Science Centre, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R., China.
The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration of alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone to resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Gram-positive bacteria.
View Article and Find Full Text PDFExploring Divergent Role of Amine in Chemodivergent Synthesis of 4-alkyl/aryl-3H-1,2-Dithiole-3-thione and Ketothioamide.
Chemistry
January 2025
Central University of Gujarat, School of Chemical Sciences, Sector 30, 382030, Gandhinagar, INDIA.
The selective synthesis of 4-alkyl/aryl-3H-1,2-dithiole-3-thione in THF and water-dependent switchable product ketothioamide is demonstrated. The presented method describes explicitly the synthesis of the extremely rare positional isomer 4-alkyl/aryl-3H-1,2-dithiole-3-thione, a unique structure distinct from another positional isomer, 5-alkyl/aryl-3H-1,2-dithiole-3-thione. The unique umpolung of the nitromethyl group is exploited for solvent selective nucleophilic sulfur and amine addition.
View Article and Find Full Text PDFImaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy.
Nano Lett
January 2025
Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 23, 17165 Solna, Sweden.
Single particle profiling (SPP) is a unique methodology to study nanoscale bioparticles such as liposomes, lipid nanoparticles, extracellular vesicles, and lipoproteins in a single particle and high throughput manner. The initial version requires the single photon counting modules for data acquisition, which limits its adoptability. Here, we present imaging-based SPP (iSPP) that can be performed by imaging a spot over time in the common imaging mode with confocal detectors.
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