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| http://dx.doi.org/10.4274/tjh.galenos.2022.2022.0416 | DOI Listing |
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Subaortic pannus causing complete outlet obstruction after bioprosthetic aortic valve replacement in a patient with left ventricular assist device: a case report.
Eur Heart J Case Rep
December 2024
Heart and Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, Sydney, NSW 2010, Australia.
Background: Subaortic pannus formation complicates bioprosthetic aortic valve (AV) replacement. We report an extreme case in a continuous-flow left ventricular assist device (LVAD) patient.
Case Summary: A 49-year-old Caucasian female with dilated cardiomyopathy was bridged to transplant with a HeartWare Ventricular Assist Device (Medtronic).
Cytauxzoon brasiliensis sp. nov. (Apicomplexa: Theileriidae), a new species infecting a little-spotted-cat (Leopardus tigrinus) (Carnivora: Felidae) from Brazil.
Syst Parasitol
July 2024
Laboratório de Patologia Clínica Veterinária, Faculdade de Agronomia e Medicina Veterinária (FAV/UnB), Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, Distrito Federal, CEP: 70910-900, Brazil.
Cytauxzoon spp. have been detected in Brazil infecting mainly asymptomatic domestic cats and wild felids. However, the supposed genetic similarity with the pathogenic Cytauxzoon felis is questionable because it is based on analysis of short sequences of the 18S rRNA gene.
View Article and Find Full Text PDFPlasma-Derived Cell-Free DNA for the Diagnosis of Ocular-Involving Histiocytosis.
Ophthalmol Sci
April 2024
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.
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- The study explores the potential of using circulating tumor DNA (ctDNA) found in plasma as a noninvasive diagnostic tool for ocular-involving histiocytosis, a condition marked by cancer-driven histiocyte expansion.
- Conducted at a tertiary cancer center, the research involved 24 adult patients, focusing on detecting specific genetic mutations associated with histiocytosis through ctDNA sequencing methods.
- Results showed that ctDNA sequencing successfully identified known driver mutations in 14 patients, demonstrating high concordance with mutations found via traditional tumor sequencing, which suggests ctDNA could streamline the diagnostic process.
Mutations in the Serine/Threonine Kinase BRAF: Oncogenic Drivers in Solid Tumors.
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Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Since their discovery in 2002, mutations have been identified as clear drivers of oncogenesis in several cancer types. Currently, their incidence rate is nearly 7% of all solid tumors with BRAF V600E constituting approximately 90% of these diagnoses. In melanoma, thyroid cancer, and histiocytic neoplasms, BRAF hotspot mutations are found at a rate of about 50%, while in lung and colorectal cancers they range from 3% to 10% of reported cases.
View Article and Find Full Text PDFCirculating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.
Immunity
December 2023
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncology Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
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- * Langerhans cell histiocytosis (LCH) can lead to a form of neurodegeneration (LCH-ND) caused by clonal myeloid cells that damage the blood-brain barrier and trigger inflammation in the brain.
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