AI Article Synopsis
- Neoadjuvant short-course radiotherapy (SCRT) for locally advanced rectal cancer (LARC) is typically delivered using photons, but proton beam therapy (PBT) may reduce acute side effects and improve chemotherapy tolerance.
- A study comparing SCRT with photons and protons showed that PBT significantly lowers radiation exposure to pelvic organs like the bladder and bowel while maintaining similar treatment quality.
- The findings suggest that PBT could offer clinical benefits for LARC patients, with further implications to be detailed in future reports from the ongoing PRORECT trial.
Article Abstract
Background And Purpose: Neoadjuvant short-course radiotherapy (SCRT) followed by full-dose systemic chemotherapy is an established treatment modality in locally advanced rectal cancer (LARC). Until recently, SCRT has been exclusively delivered with photons. Proton beam therapy (PBT) may minimize acute toxicity, which in turn likely impacts favorably on the tolerability to subsequent chemotherapy. The aim of this study is a dosimetric comparison between SCRT with photons and protons in the randomized phase II trial PRORECT (NCT04525989).
Materials And Methods: From June 2021 to June 2022, twenty consecutive patients with LARC have been treated according to study protocol. For each patient, both a VMAT and a PBT treatment plans have been generated and compared pairwise.
Results: Dose-volume histogram (DVH) analysis revealed that SCRT with protons significantly reduced radiation dose to pelvic organs at risk including bladder, bones, and bowel in comparison to SCRT with photons. Photon and proton treatment plans had equivalent conformity and homogeneity indexes.
Conclusion: Preoperative SCRT with protons offers a significant reduction of radiation dose to normal tissues compared with current photon-based radiotherapy technique. Demonstrated dosimetric advantages may translate into measurable clinical benefits in patients with LARC. Clinical implications of the dosimetric superiority of SCRT with protons will be presented in the coming reports from the PRORECT trial.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792362 | PMC |
| http://dx.doi.org/10.1016/j.ctro.2022.100562 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparing robust proton versus online adaptive photon radiotherapy for short-course treatment of rectal cancer.
Phys Imaging Radiat Oncol
October 2024
Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway.
Background And Purpose: Image-guided proton beam therapy (IG-PBT) and cone-beam CT (CBCT)-based online adaptive photon radiotherapy (oART) have potentials to restrict radiation toxicity. They are both hypothesised to reduce therapy limiting bowel toxicity in the multimodality treatment of locally advanced rectal cancer (LARC). This study aimed to quantify the difference in relevant dose-volume metrics for these modalities.
View Article and Find Full Text PDFParallel explorations in LA-NSCLC: Chemoradiation dose-response optimisation considering immunotherapy and cardiac toxicity sparing.
Radiother Oncol
November 2024
Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom. Electronic address:
Background And Purpose: Chemoradiotherapy (CRT) for locally-advanced non-small cell lung cancer (LA-NSCLC) has undergone advances, including increased overall survival (OS) when combined with immune checkpoint blockade (ICB), and using cardiac-sparing techniques to reduce the radiotoxicity. This research investigated 1) how radiotherapy schedules can be optimised with CRT-ICB schemes, and 2) how cardiac-sparing might change the OS for concurrent CRT (cCRT).
Methods And Materials: Survival data and dosimetric indices were sourced from published studies, with 2-year OS standardised and the hazard ratio of mean heart dose (MHD) against radiotoxicity tabulated in purpose.
The impact of different modalities of chemoradiation therapy and chemotherapy regimens on lymphopenia in patients with locally advanced non-small cell lung cancer.
Transl Lung Cancer Res
June 2024
Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Background: Chemotherapy and radiotherapy (RT) would induce lymphopenia, leading to a poor prognosis. This study investigated whether chemotherapy increased lymphopenia during RT and explored the impacts of different chemotherapy regimens on the lymphocyte counts of patients receiving RT.
Methods: Clinical parameters and lymphocyte data were collected from 215 patients with locally advanced non-small cell lung cancer (LA-NSCLC).
Preoperative short-course radiation therapy with PROtons compared to photons in high-risk RECTal cancer (PRORECT): Initial dosimetric experience.
Clin Transl Radiat Oncol
March 2023
Department of Radiation Oncology, Karolinska University Hospital, Stockholm, Sweden.
Article Synopsis
- Neoadjuvant short-course radiotherapy (SCRT) for locally advanced rectal cancer (LARC) is typically delivered using photons, but proton beam therapy (PBT) may reduce acute side effects and improve chemotherapy tolerance.
- A study comparing SCRT with photons and protons showed that PBT significantly lowers radiation exposure to pelvic organs like the bladder and bowel while maintaining similar treatment quality.
- The findings suggest that PBT could offer clinical benefits for LARC patients, with further implications to be detailed in future reports from the ongoing PRORECT trial.
Functional characterization of a novel disaccharide transporter in lobster hepatopancreas.
J Comp Physiol B
May 2017
Department of Biology, University of North Florida, Jacksonville, FL, 32223, USA.
In animals, the accepted model of carbohydrate digestion and absorption involves reduction of disaccharides into the monosaccharides glucose, fructose, and galactose followed by their individual transmembrane transport into cells. In 2011, a gene for a distinct disaccharide sucrose transporter (SCRT) was found in Drosophila melanogaster and characterized in a yeast expression system. The purpose of the present investigation was to functionally identify and characterize a putative disaccharide transporter analog in the hepatopancreas of the American lobster, Homarus americanus.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!