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| http://dx.doi.org/10.1186/s12974-022-02649-x | DOI Listing |
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Clinical effects of CYP2D6 phenoconversion in patients with psychosis.
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Outpatient Clinic Pharmacogenetics, Parnassia Groep, Amsterdam, The Netherlands.
Background: Pharmacogenetics is considered a promising avenue for improving treatment outcomes, yet evidence arguing for the use of pharmacogenetics in the treatment of psychotic disorders is mixed and clinical usefulness is under debate. Many patients with psychosis use multiple medications, which can alter the metabolic capacity of enzymes, a process called phenoconversion. In clinical studies, treatment outcomes of drugs for psychosis management may have been influenced by phenoconversion.
View Article and Find Full Text PDFAmada N, Hirose T, Suzuki M, Kakumoto Y, Futamura T, Maeda K, et al. Synergistic anti-depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice. Neuropsychopharmacol Rep.
View Article and Find Full Text PDFNMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression.
J Pharm Biomed Anal
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College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310006, China; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, Zhejiang University of Technology, Hangzhou 310006, China. Electronic address:
Depression currently ranks as the fourth leading cause of disability globally, affecting approximately 20% of the world's population. we established a chronic restraint stress (CRS) induced depression model in mice and employed fluoxetine as a reference drug. We assessed the therapeutic potential of saffron essential oil (SEO) and elucidated its underlying mechanisms through behavioral indices and NMR-based metabolomic analysis.
View Article and Find Full Text PDFEffect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
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Department of Anesthesiology and Pain Medicine, Gyeongsang National University College of Medicine, Gyeongsang National University Hospital, Jinju-si, Republic of Korea.
Article Synopsis
- Lipid emulsion has been found to be effective in treating serious cardiovascular issues caused by toxic levels of certain neuropsychiatric drugs, particularly those that are lipophilic (fat-soluble).
- A study analyzed case reports to evaluate how lipid emulsions impacted patient recovery based on the Glasgow Coma Scale and corrected QT intervals, focusing on specific drugs like amitriptyline and trazodone.
- Results showed that 98.3% of patients improved with lipid emulsion treatment, although more research is necessary to fully understand its effects and optimize its use.
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