Objectives: To estimate the impact of the organisational model of transvenous lead extraction (TLE) on effectiveness and safety of procedures.
Design: Post hoc analysis of patient data entered prospectively into a computer database.
Setting: Data of all patients undergoing TLE in three centres in Poland between 2006 and 2021 were analysed.
Participants: 3462 patients including: 985 patients undergoing TLE in a hybrid room (HR), with cardiac surgeon (CS) as co-operator, under general anaesthesia (GA), with arterial line (AL) and with transoesophageal echocardiography (TEE) monitoring (group 1), 68 patients-TLE in HR with CS, under GA, without TEE (group 2), 406 patients-TLE in operating theatre (OT) using 'arm-C' X-ray machine with CS under GA and with TEE (group 3), 154 patients-TLE in OT with CS under GA, without TEE (group 4), 113 patients-TLE in OT with anaesthesia team, using the 'arm-C' X-ray machine, without CS (group 5), 122 patients-TLE in electrophysiology lab (EPL), with CS under intravenous analgesia without TEE and AL (group 6), 1614 patients-TLE in EPL, without CS, under intravenous analgesia without TEE and AL (group 7).
Key Outcome Measure: Effectiveness and safety of TLE depending on organisational model.
Results: The rate of major complications (MC) was higher in OT/HR than in EPL (2.66% vs 1.38%), but all MCs were treated successfully and there was no MC-related death. The use of TEE during TLE increased probability of complete procedural succemss achieving about 1.5 times (OR=1.482; p<0.034) and were connected with reduction of minor complications occurrence (OR=0.751; p=0.046).
Conclusions: The most important condition to avoid death due to MC is close co-operation with cardiac surgery team, which permits for urgent rescue cardiac surgery. Continuous TEE monitoring plays predominant role in immediate decision on rescue sternotomy and improves the effectiveness of procedure.
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http://dx.doi.org/10.1136/bmjopen-2022-062952 | DOI Listing |
Obesity (Silver Spring)
January 2025
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Objective: The objective of this study was to examine the independent and interactive effects of insulin sensitivity (S), the acute insulin response to glucose, and diet on changes in fat mass (FM), resting and total energy expenditure (REE and TEE, respectively), and mechanical efficiency, during weight loss, in African American women with obesity.
Methods: A total of 69 women were randomized to low-fat (55% carbohydrate [CHO], 20% fat) or low-CHO (20% CHO, 55% fat) hypocaloric diets for 10 weeks, followed by a 4-week weight-stabilization period (controlled feeding). S and acute insulin response to glucose were measured at baseline with an intravenous glucose tolerance test; body composition was measured with bioimpedance analysis at baseline and week 10; and REE, TEE, and mechanical efficiency were measured with indirect calorimetry, doubly labeled water, and a submaximal bike test, respectively, at baseline and week 14.
Nat Commun
December 2024
Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism Digestion and Reproduction, Imperial College London, London, UK.
Lactobacillus species dominance of the vaginal microbiome is a hallmark of vaginal health. Pathogen displacement of vaginal lactobacilli drives innate immune activation and mucosal barrier disruption, increasing the risks of STI acquisition and, in pregnancy, of preterm birth. We describe differential TLR mediated activation of the proinflammatory transcription factor NF-κB by vaginal pathogens and commensals.
View Article and Find Full Text PDFIntroduction: Canadian youth mental health (YMH) systems have the potential to urgently tackle the mental health treatment gap currently impacting young people, and stepped care (SC) is one model that can address this need. The adoption of SC models can guide the development of better-connected YMH systems by simplifying transitions and care pathways. To do so requires robust standards that are co-created across stakeholder groups, including with lived experience experts, to ensure the effective implementation of SC models.
View Article and Find Full Text PDFBr J Radiol
December 2024
Rheumatology Unit, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh, Malaysia.
Objectives: This study explores the correlation between volunteer demographics with enthesis stiffness and intra and inter -observer agreements using shear wave elastography (SWE).
Methods: 98 healthy volunteers were recruited. SWE was performed on quadriceps, suprapatellar, infrapatellar, and Achilles entheses.
J Atheroscler Thromb
December 2024
Department of Neurology, Juntendo University Urayasu Hospital.
Aims: Atherogenic dyslipidemia (AD) is regarded as a residual risk of cardiovascular diseases characterized by low high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels and related to the intracranial stenosis of atheromatous thrombotic brain infarction (ATBI). Further, atherosclerosis is possibly related to another stroke subtype, including cryptogenic stroke (CS). In particular, an aortic complicated lesion (ACL) is a notable embolic source of CS, since recurrence of aortogenic brain embolism is not rare.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!