Should we really include systemic sclerosis specific antibodies in the classification criteria of Sjogren's disease?

Semin Arthritis Rheum

Department of Internal Medicine, CHU Rennes, University of Rennes 1, Rennes, France; Department of Rheumatology, CHU Rennes, University of Rennes 1, Rennes, France; INSERM, Rennes University Hospital, UMR 1241, Institut NuMeCan (Nutrition Metabolisms and Cancer), University Rennes, France; CHU Rennes, Inserm, EHESP, Institut de Recherche en Santé, Environnement et Travail UMR_S 1085, Rennes, France.

Published: February 2023

AI Article Synopsis

  • The authors find the findings from Marketos et al. intriguing, particularly about the presence of certain auto-antibodies in patients with sicca symptoms.
  • They suggest that these scleroderma-related antibodies may indicate a link between scleroderma and Sjogren's syndrome rather than just pointing towards Sjogren's alone.
  • The authors believe that these antibodies could signal undiagnosed scleroderma, emphasizing the need for further investigation.

Article Abstract

We have read with great interest the results from Marketos et al. regarding the positivity of specific systemic sclerosis auto-antibodies in patients with sicca symptoms. Based on complementary data from the literature, we rather believe scleroderma-associated antibodies should be considered either as a yellow flag for an association between scleroderma and Sjogren, or a potential undiagnosed scleroderma, rather than an isolated Sjogren's disease.

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Source
http://dx.doi.org/10.1016/j.semarthrit.2022.152158DOI Listing

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