Purpose: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to assess the influence of head movement on the signal before and after retrospective motion correction.
Methods: MPRAGE data from a tumor patient were used to simulate dynamic Z-spectra under the influence of motion. The DGE responses for different tissue types were simulated, creating a ground truth. Rigid head movement patterns were applied as well as physiological dilatation and pulsation of the lateral ventricles and head-motion-induced B -changes in presence of first-order shimming. The effect of retrospective motion correction was evaluated.
Results: Motion artifacts similar to those previously reported for in vivo DGE data could be reproduced. Head movement of 1 mm translation and 1.5 degrees rotation led to a pseudo-DGE effect on the order of 1% signal change. B effects due to head motion altered DGE changes due to a shift in the water saturation spectrum. Pseudo DGE effects were partly reduced or enhanced by rigid motion correction depending on tissue location.
Conclusion: DGE MRI studies can be corrupted by motion artifacts. Designing post-processing methods using retrospective motion correction including B correction will be crucial for clinical implementation. The proposed phantom should be useful for evaluation and optimization of such techniques.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992166 | PMC |
| http://dx.doi.org/10.1002/mrm.29563 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.
Sci Rep
January 2025
Department of Psychiatry, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Childhood abuse represents one of the most potent risk factors for the development of psychopathology during childhood, accounting for 30-60% of the risk for onset. While previous studies have separately associated reductions in gray matter volume (GMV) with childhood abuse and internalizing psychopathology (IP), it is unclear whether abuse and IP differ in their structural abnormalities, and which GMV features are related to abuse and IP at the individual level. In a pooled multisite, multi-investigator sample, 246 child and adolescent females between the ages of 8-18 were recruited into studies of interpersonal violence (IPV) and/or IP (i.
View Article and Find Full Text PDFMRI-Based Circumferential Strain in Boys with Early Duchenne Muscular Dystrophy Cardiomyopathy.
Diagnostics (Basel)
November 2024
Department of Radiology, Stanford University, Palo Alto, CA 94305, USA.
In boys with Duchenne muscular dystrophy (DMD), cardiomyopathy has become the primary cause of death. Although both positive late gadolinium enhancement (LGE) and reduced left ventricular ejection fraction (LVEF) are late findings in a DMD cohort, LV end-systolic circumferential strain at middle wall (E) serves as a biomarker for detecting early impairment in cardiac function associated with DMD. However, E derived from cine Displacement Encoding with Stimulated Echoes (DENSE) has not been quantified in boys with DMD.
View Article and Find Full Text PDFDynamic Glucose Enhanced Imaging using Direct Water Saturation.
ArXiv
October 2024
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, US.
Article Synopsis
- Dynamic glucose enhanced (DGE) MRI, using techniques like CEST or CESL, aims to analyze glucose uptake but faces challenges with low sensitivity and motion artifacts.
- The new method proposed, called DS-DGE MRI, leverages linewidth broadening in water saturation spectra during glucose infusion to improve measurements.
- Initial tests on brain tumor patients show that DS-DGE MRI produces detailed area-under-the-curve maps that effectively highlight tumor regions, indicating its potential over existing imaging techniques.
Dynamic glucose-enhanced MRI of gliomas: A preliminary clinical application.
NMR Biomed
January 2025
Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
The study aimed to investigate the feasibility of dynamic glucose-enhanced (DGE) MRI technology in the clinical application of glioma. Twenty patients with glioma were examined using a preoperative DGE-MRI protocol before clinical intervention. A brief hyperglycemic state was achieved by injecting 50 mL of 50% w/w D-glucose intravenously during the DGE imaging.
View Article and Find Full Text PDFSelective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation.
Proc Natl Acad Sci U S A
November 2024
McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
Article Synopsis
- RNA oxidation, particularly the formation of 8-oxo-7,8-dihydroguanosine (8-oxo-rG), serves as a key indicator of oxidative stress in cells.
- Polynucleotide phosphorylase (PNPase) helps protect cells from oxidative stress by recognizing and degrading RNA containing 8-oxo-rG, but how 8-oxo-rG affects this process was previously unclear.
- This study finds that 8-oxo-rG causes PNPase to stall during RNA degradation, particularly due to a crucial residue (Arg399), influencing bacterial survival under stress conditions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!