AI Article Synopsis
- Diabetic foot ulcers (DFUs) are a significant and growing health issue for diabetes patients, leading to increased morbidity and emphasizing the need for effective diagnosis and treatment.
- The wound healing process involves three stages: inflammation, proliferation, and regeneration, and the role of non-coding RNAs (ncRNAs) has gained attention in understanding these stages and diabetes complications.
- Dysregulation of ncRNAs may contribute to DFU progression and delayed healing, making them potential targets for new diagnostic and therapeutic strategies in managing diabetic wounds.
Article Abstract
Diabetic foot ulcer (DFU) and poor wound healing are chronic complications in patients with diabetes. The increasing incidence of DFU has resulted in huge pressure worldwide. Diagnosing and treating this condition are therefore of great importance to control morbidity and improve prognosis. Finding new markers with potential diagnostic and therapeutic utility in DFU has gathered increasing interest. Wound healing is a process divided into three stages: Inflammation, proliferation, and regeneration. Non-coding RNAs (ncRNAs), which are small protected molecules transcribed from the genome without protein translation function, have emerged as important regulators of diabetes complications. The deregulation of ncRNAs may be linked to accelerated DFU development and delayed wound healing. Moreover, ncRNAs can be used for therapeutic purposes in diabetic wound healing. Herein, we summarize the role of microRNAs, long ncRNAs, and circular RNAs in diverse stages of DFU wound healing and their potential use as novel therapeutic targets.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791568 | PMC |
| http://dx.doi.org/10.4239/wjd.v13.i12.1001 | DOI Listing |
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