AI Article Synopsis
- Endometrial cancer is a major health issue that contributes to decreased life expectancy and is one of the most common cancers among women globally, with rising mortality linked to increasing obesity rates.
- Adipose tissue produces adipocytokines that influence various cancer-related processes, such as cell growth, invasion, inflammation, and resistance to cell death.
- Understanding how these adipocytokines work could lead to new treatment options for endometrial cancer, highlighting the need for more extensive research on adipocytokines and potential therapeutic approaches to combat gynecological cancers.
Article Abstract
Endometrial cancer is considered a significant barrier to increasing life expectancy and remains one of the most common malignant cancers among women in many countries worldwide. The increasing mortality rates are potentially proportional to the increasing obesity incidence. Adipose tissue secretes numerous adipocytokines, which may play important roles in endometrial cancer progression. In this scenario, we describe the role of adipocytokines in cell proliferation, cell invasion, cell adhesion, inflammation, angiogenesis, and anti-apoptotic action. A better understanding of the mechanisms of these adipocytokines may open up new therapeutic avenues for women with endometrial cancer. In the future, larger prospective studies focusing on adipocytokines and specific inhibitors should be directed at preventing the rapidly increasing prevalence of gynecological malignancies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791063 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.1090227 | DOI Listing |
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