Microsporidia is a phylum of intracellular parasites that secrete spores and stay in water sources. These parasites can cause infection in humans by invading the digestive system, the urinary system, the muscular system and the eye. Recently, the Israeli Ministry of Health announced that dozens of people in Israel were suspected of being infected with microsporidial keratitis after bathing in the waters of the Kinneret (Sea of Galilee). Here we present a brief overview of this microsporidial keratitis as well as three case presentations.
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Digital PCR detection of microsporidia in household pipe water of patients with microsporidial keratitis.
Sci Rep
January 2025
Department of Ophthalmology, School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
This is a prospective non-comparative experimental study aimed to investigate the presence of microsporidia in household pipe water of microsporidial keratitis (MK) patients and to describe the patients' characteristics and behavioral risk factors. This study was conducted at Walailak University Hospital, Thailand, from July 2022 to February 2024. Patients diagnosed with MK were surveyed using a questionnaire to assess personal behaviors and source of household water.
View Article and Find Full Text PDFClinical characteristics, progression patterns and treatment outcomes in microsporidial keratoconjunctivitis: a prospective study in Thailand.
Int Ophthalmol
November 2024
Department of Ophthalmology, Phramongkutklao Hospital, 315 Ratchawithi Road, Thung Phayathai Subdistrict, Ratchathewi, Bangkok, 10400, Thailand.
Purpose: To assess the clinical characteristics, progression patterns, and treatment outcomes of microbiologically confirmed microsporidial keratoconjunctivitis (MKC).
Methods: This prospective cross-sectional study included patients with superficial punctate epithelial keratitis clinically suspected of MKC. Comprehensive slit-lamp examinations were conducted, and corneal scraping was performed for Gram-chromotrope staining and polymerase chain reaction (PCR) analysis.
[Advances in clinical diagnosis and treatment of microsporidial keratitis].
Zhonghua Yan Ke Za Zhi
October 2024
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.
Article Synopsis
- Microsporidia, a type of unicellular microorganism, can infect the eyes and lead to a condition known as microsporidia keratitis (MK), which has two forms: microsporidian keratoconjunctivitis (MKC) and stromal keratitis (MSK).
- MKC generally improves on its own, but can escalate to MSK, a severe condition that risks vision and could cause corneal perforation.
- Despite its prevalence in Southeast Asia, especially during the rainy season, there's a lack of detailed case reports and understanding of MK in China, resulting in challenges with diagnosis and treatment, which this review aims to address.
Microsporidial stromal keratitis: treatment outcomes, clinical manifestations, confocal microscopy and histopathology findings: a retrospective observational study.
BMJ Open Ophthalmol
September 2024
Ophthalmology, Chulalongkorn University Faculty of Medicine, Bangkok, Thailand
Objective: Microsporidial stromal keratitis (MSK) is an uncommon disease. Only several case series have been reported. We aimed to describe the clinical manifestations, histopathology and treatment outcomes of MSK.
View Article and Find Full Text PDFKeratic Precipitates: An Overlooked Sign of Microsporidial Stromal Keratitis?
Ocul Immunol Inflamm
November 2024
Cornea and Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, India.
Purpose: To elucidate a distinctive clinical feature in cases of microsporidial stromal keratitis (MSK).
Method: A retrospective observational study of cases with a histopathological and/or microbiological diagnosis of MSK on corneal biopsy or host corneal button between 2016 and 2022 was conducted.
Results: Eighteen cases with a confirmed histopathological and/or microbiological diagnosis of MSK were detected.
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