Introduction: Colorectal cancer (CRC) is a common cancer. As metastasis and recurrence are main causes of CRC death, it is of great significance to find prognostic biomarkers.
Methods: Data related to CRC were collected from GEO database. The patients were grouped based on clinical information, and the differentially expressed genes (DEGs) were obtained by differential analysis. GO and KEGG pathway enrichment analyses were conducted based on DEGs. Cox combined with LASSO regression analysis was applied to screen out the key genes that used to build the prognostic model. Survival curve and receiver operating characteristic curve were employed to evaluate the validity and reliability of the model. Cox regression analysis was applied to determine the independence of risk score. GSEA and GSVA analyses were performed on patients with different risks according to the risk model scores, and the prognostic nomogram was plotted combined with clinical data. Also, qRT-PCR was applied to examine the expression status of the screened signatures in clinical cases.
Results: We obtained 302 DEGs by dividing CRC patients into early-stage and advanced-stage groups. The results of enrichment analyses demonstrated that the DEGs were mainly concentrated in tissues of extracellular matrix, epithelial cell proliferation, and cell adhesion-related pathways. Regression identified 9 hub genes notably correlated with prognosis, including CLK1, SLC2A3, LIPG, EPHB2, ATOH1, PLCB4, GZMB, CKMT2, and CXCL11. The validation of the risk model proved that the risk model was accurate and could independently determine the prognosis of patients. Finally, differences were found in pathway activity of extracellular matrix secretion, plaque secretion, Notch signaling pathway, and tight junctions in high-risk and low-risk patients. In addition to LIPG and CKMT2, other feature genes were notably overexpressed in CRC tumor tissues.
Conclusion: The results proved that the expression levels of the 9 biomarkers could be used to predict the prognosis of CRC patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000528084 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease.
J Neuropsychol
January 2025
Department of Health, Medical and Neuropsychology, Leiden University, Leiden, The Netherlands.
Up to 45% of patients with Parkinson's disease (PD) experience impulse control disorders (ICDs), characterized by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development of ICDs in PD. A total of 278 de novo PD patients (ICD-free at enrollment) were selected from the Parkinson's Progression Markers Initiative database.
View Article and Find Full Text PDFLong COVID and its risk factors in migrants: a nationwide register study from Sweden.
BMC Med
January 2025
Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.
Background: Many studies have found more severe COVID-19 outcomes in migrants and ethnic minorities throughout the COVID-19 pandemic, while recent evidence also suggests higher risk of longer-term consequences. We studied the risk of a long COVID diagnosis among adult residents in Sweden, dependent on country of birth and accounting for known risk factors for long COVID.
Methods: We used linked Swedish administrative registers between March 1, 2020 and April 1, 2023, to estimate the risk of a long COVID diagnosis in the adult population that had a confirmed COVID-19 infection.
Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education.
BMC Health Serv Res
January 2025
Pain Research Unit, Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Evidence-based treatment of chronic pain requires a multidisciplinary approach grounded in the biopsychosocial model. Implementing this approach within health systems relies on its acceptance by both healthcare providers and patients. While pioneering multidisciplinary pain clinics can serve as a model for implementation, a systematic effort is needed to share knowledge effectively and broadly.
View Article and Find Full Text PDFHealth-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions.
BMC Sports Sci Med Rehabil
January 2025
Department of Sport Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.
Background: Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions is crucial, especially when underlying causes are unknown.
View Article and Find Full Text PDFAssociation between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study.
Ital J Pediatr
January 2025
High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Background: Attention-Deficit Hyperactivity Disorder (ADHD) is a complex disease that negatively impacts the social and academic/occupational activities of children and is more common in boys than in girls.
Methods: This case-control study aimed to assess the association between some environmental risk factors and ADHD among children in Alexandria, Egypt. It was carried out at the outpatient clinics of El Shatby Pediatric University Hospital in Alexandria, Egypt, with 252 children (126 cases and 126 controls).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!