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Intracranial artery stenosis is associated with cortical thinning in stroke-free individuals of two longitudinal cohorts. | LitMetric

AI Article Synopsis

  • - The study investigated the link between asymptomatic intracranial artery stenosis (aICAS) and cortical thickness using brain imaging in two groups of stroke-free participants: NOMAS and NACC.
  • - A total of 1209 participants from NOMAS and 392 from NACC were analyzed, revealing an inverse relationship between stenosis score and total cortical thickness, particularly stronger for posterior circulation stenosis.
  • - The findings suggest that both types of aICAS are linked to thinning of the cortical layer in the brain, indicating potential underlying mechanisms beyond just blood flow issues.

Article Abstract

Background: We examined the association between asymptomatic intracranial artery stenosis (aICAS) and cortical thickness using brain magnetic resonance morphometry in two cohorts.

Methods: This cross-sectional study included stroke-free participants from the Northern Manhattan Study (NOMAS) and the National Alzheimer's Coordinating Center (NACC). We represented the predictor aICAS in NOMAS as a continuous global stenosis score reflecting an overall burden of stenosis (possible range 0-44) assessed by magnetic resonance angiography and in NACC as a dichotomous autopsy-determined Circle of Willis (CoW) atherosclerosis (none-mild vs moderate-severe). The primary outcome of interest was total cortical thickness. We analyzed each dataset separately using multivariable linear regression.

Results: The analysis included 1209 NOMAS (46% had any stenosis, 5% had ≥70% stenosis of at least one vessel; stenosis score range 0-11) and 392 NACC (36% moderate-severe CoW atherosclerosis) participants. We found an inverse relationship between stenosis score and total cortical thickness (β-estimate [95% confidence interval (CI)]: -2.98 [-5.85, -0.11]) in adjusted models. We replicated these results in NACC (β-estimate [95% CI]: -0.06 [-0.11, -0.003]). Post-hoc, we segregated stenosis scores by location and only posterior circulation stenosis score was associated with total cortical thickness (anterior β-estimate [95% CI]: -0.90 [-5.16, 3.36], posterior β-estimate [95% CI]: -7.25 [-14.30, -0.20]).

Conclusion: We found both radiographically and neuropathologically determined aICAS to be associated with global cortical thinning. Interestingly, posterior circulation stenoses appeared to drive this association with global cortical thinning, raising the possibility of pathophysiologic mechanisms for cortical thinning other than impaired hemodynamics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880900PMC
http://dx.doi.org/10.1016/j.jns.2022.120533DOI Listing

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